Mechanisms of DNA Damage and Repair

Implications for Carcinogenesis and Risk Assessment

  • Michael G. Simic
  • Lawrence Grossman
  • Arthur C. Upton
  • David S. Bergtold

Part of the Basic Life Sciences book series (volume 189)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

  3. DNA Damage

    1. Mechanism of Damage

      1. Paul M. Cullis, Martyn C. R. Symons
        Pages 29-37
      2. Michael G. Simic, Slobodan V. Jovanovic
        Pages 39-49
      3. Jane E. Frew, Peter Jones, George Scholes Radiation and Biophysical Chemistry Laboratory
        Pages 61-67
      4. Jean Cadet, Maurice Berger, Anthony Shaw
        Pages 69-74
    2. Damage in Cellls

About this book

Introduction

This book is based on the papers presented at the conference on "Mecha­ nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

Keywords

DNA DNA damage Nucleotid Protein cancer cells ionizing kinetics mutation paper polymer population radiation risk assessment ultraviolet

Editors and affiliations

  • Michael G. Simic
    • 1
    • 2
  • Lawrence Grossman
    • 3
  • Arthur C. Upton
    • 4
  • David S. Bergtold
  1. 1.National Bureau of StandardsGaithersburgUSA
  2. 2.Chemistry DepartmentAmerican UniversityUSA
  3. 3.Johns Hopkins UniversityBaltimoreUSA
  4. 4.New York University Medical CenterNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-9462-8
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-9464-2
  • Online ISBN 978-1-4615-9462-8
  • About this book