Mechanisms of DNA Damage and Repair

Implications for Carcinogenesis and Risk Assessment

  • Michael G. Simic
  • Lawrence Grossman
  • Arthur C. Upton
  • David S. Bergtold

Part of the Basic Life Sciences book series (volume 189)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

  3. DNA Damage

    1. Mechanism of Damage

      1. Paul M. Cullis, Martyn C. R. Symons
        Pages 29-37
      2. Michael G. Simic, Slobodan V. Jovanovic
        Pages 39-49
      3. Jane E. Frew, Peter Jones, George Scholes Radiation and Biophysical Chemistry Laboratory
        Pages 61-67
      4. Jean Cadet, Maurice Berger, Anthony Shaw
        Pages 69-74
    2. Damage in Cellls

    3. DNA Binding Drugs

  4. DNA Repair and Consequences

    1. Lorraine Marsh, Graham C. Walker
      Pages 273-280
    2. Antonia M. Pedrini, Silvia Tornaletti, Paola Menichini, Angelo Abbondandolo
      Pages 295-301
    3. Paul Modrich
      Pages 303-310
    4. E. C. Friedberg, D. P. Barbis, J. M. Chenevert, R. Fleer, D. Kalainov, L. Naumovski et al.
      Pages 311-318
    5. Tomas Lindahl
      Pages 335-340
    6. Lawrence A. Loeb, Bradley D. Preston, Elizabeth T. Snow, Roeland M. Schaaper
      Pages 341-347
    7. Bernard Weiss, Hiyam H. El-Hajj
      Pages 349-356
    8. Franklin Hutchinson, Richard D. Wood
      Pages 377-383
    9. Helmut Zarbl, Saraswati Sukumar, Anne L. Arthur, Dionisio Martin-Zanca, Mariano Barbacid
      Pages 385-397
    10. Michael D. Cole
      Pages 399-406
    11. Barry W. Glickman, Douglas F. Fix, Fumio Yatagai, Philip A. Burns, Roel M. Schaaper
      Pages 425-437
  5. Risk Assessment

    1. H. Ohshima, B. Pignatelli, J. Nair, N. Munoz, S. Calmels, M. Crespi et al.
      Pages 453-461
    2. Steven R. Tannenbaum, Paul L. Skipper
      Pages 473-478

About this book


This book is based on the papers presented at the conference on "Mecha­ nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.


DNA DNA damage Nucleotid Protein cancer cells ionizing kinetics mutation paper polymer population radiation risk assessment ultraviolet

Editors and affiliations

  • Michael G. Simic
    • 1
    • 2
  • Lawrence Grossman
    • 3
  • Arthur C. Upton
    • 4
  • David S. Bergtold
  1. 1.National Bureau of StandardsGaithersburgUSA
  2. 2.Chemistry DepartmentAmerican UniversityUSA
  3. 3.Johns Hopkins UniversityBaltimoreUSA
  4. 4.New York University Medical CenterNew YorkUSA

Bibliographic information