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The Inactivation of Sodium Channels in the Node of Ranvier and Its Chemical Modification

  • Chapter
Ion Channels

Abstract

The upstroke of the action potential in most axons is caused by a transitory influx of Na+ ions. It has been known from voltage clamp experiments for almost 40 years that the membrane permeability to Na+ increases on depolarization and decreases on repolarization. However, it also decreases on maintained depolarization, a process termed inactivation, which leaves the membrane incapable of passing Na+ on renewed depolarization for a few milliseconds, thus rendering it refractory (Hodgkin and Huxley, 1952).

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  1. Physiology Institute, University of Kiel, D-2300, Kiel, Federal Republic of Germany

    Werner Ulbricht

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  1. Northwestern University Medical School, Chicago, Illinois, USA

    Toshio Narahashi

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Ulbricht, W. (1990). The Inactivation of Sodium Channels in the Node of Ranvier and Its Chemical Modification. In: Narahashi, T. (eds) Ion Channels. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7305-0_4

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