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Chemical, Anatomical, and Physiological Studies on Human Pancreatic and Rat Hypothalamic Growth Hormone-Releasing Factor

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Human Growth Hormone

Abstract

The hypothalamic regulation of growth hormone (GH) secretion is mediated by stimulatory and inhibitory factors, both of which reach the adenohypophysis via the hypothalamic—hypophysial portal system.(1,2) Somatostatin, which exerts inhibitory control over the secretion of GH, was purified from ovine hypothalamic extracts and characterized over 10 years ago(3) as a tetradecapeptide, and subsequently a biologically active, iV-terminally extended, 28-amino-acid long form was identified in duodenal(4) and hypothalamic extracts.(5–7) Prior to 1982, several agents with GH-releasing activity had been described; none, however, were of high potency or otherwise fulfill the criteria expected of a physiological GH-releasing factor (GRF).

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Author information

Authors and Affiliations

  1. The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California, 92037, USA

    Wylie Vale, Joan Vaughan, Hans Seifert, Louise Bilezikjian, Marilyn Perrin, Joachim Spiess & Jean Rivier

  2. Developmental Neurobiology Laboratory, The Salk Institute, La Jolla, California, 92037, USA

    Paul Sawchenko & Larry Swanson

  3. Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, 22901, USA

    Michael O. Thorner

Authors
  1. Wylie Vale
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  2. Joan Vaughan
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  3. Paul Sawchenko
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  4. Hans Seifert
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  5. Louise Bilezikjian
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  6. Marilyn Perrin
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  7. Larry Swanson
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  8. Michael O. Thorner
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  9. Joachim Spiess
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  10. Jean Rivier
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Editor information

Editors and Affiliations

  1. National Hormone and Pituitary Program, Baltimore, Maryland, USA

    Salvatore Raiti

  2. National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA

    Robert A. Tolman

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© 1986 Plenum Publishing Corporation

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Vale, W. et al. (1986). Chemical, Anatomical, and Physiological Studies on Human Pancreatic and Rat Hypothalamic Growth Hormone-Releasing Factor. In: Raiti, S., Tolman, R.A. (eds) Human Growth Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7201-5_26

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  • DOI: https://doi.org/10.1007/978-1-4615-7201-5_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7203-9

  • Online ISBN: 978-1-4615-7201-5

  • eBook Packages: Springer Book Archive

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