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Human Growth Hormone

  • Salvatore Raiti
  • Robert A. Tolman

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction I

    1. Salvatore Raiti
      Pages 1-11
  3. Introduction II

    1. Robert A. Tolman
      Pages 13-18
  4. Hypopituitarism and Hyperpituitarism

    1. Front Matter
      Pages 19-19
    2. Henry G. Friesen, Heather J. Dean, Susan Kasper
      Pages 21-28
    3. Mark E. Molitch
      Pages 29-50
    4. Salvatore Raiti, S. L. Kaplan, W. V. Moore, J. S. Parks, M. H. MacGillivray, A. W. Root et al.
      Pages 77-83
    5. Wayne V. Moore, Libbie J. Russo
      Pages 85-91
    6. Robert M. Blizzard, Susan Joyce, Tina Mitchell, Ann J. Johanson, Samuel Libber, Leslie P. Plotnick et al.
      Pages 93-106
  5. Human Growth Hormone in other Forms of Short Stature

    1. Front Matter
      Pages 107-107
    2. Salvatore Raiti, S. L. Kaplan, G. P. August, S. A. Kaplan, M. H. MacGillivray, W. V. Moore et al.
      Pages 109-113
    3. G. Van Vliet, D. M. Styne, S. L. Kaplan, M. M. Grumbach
      Pages 115-121
    4. Salvatore Raiti, S. L. Kaplan, G. P. August, S. A. Kaplan, M. H. MacGillivray, W. V. Moore et al.
      Pages 123-126
    5. Daniel Rudman, Rajender K. Chawla, William P. Heath, Carol J. Berry, Michael H. Kutner
      Pages 135-162
    6. Zvi Laron, Aviva Silbergeld, Athalia Pertzelan, Rina Eshet
      Pages 163-178
    7. John A. Phillips III, Angel Ferrandez, Herwig Frisch, Ruth Illig, Klaus Zuppinger
      Pages 211-226
  6. Biosynthesis of Human Growth Hormone

    1. Front Matter
      Pages 227-227
    2. D. R. Bangham
      Pages 229-240
    3. Michael J. Ross, Kenneth C. Olson, Michael D. Geier, John V. O’Connor, Andrew J. S. Jones
      Pages 241-256
    4. Linda Fryklund, Johnny Brandt, Magnus Hagerman, Bohdan Pavlu, Bo Skoog, Anders Wichman
      Pages 257-266
    5. S. L. Kaplan, L. E. Underwood, G. P. August, J. J. Bell, S. L. Blethen, D. R. Brown et al.
      Pages 267-277
  7. Control of Growth Hormone Secretion, Growth Hormone-Releasing Factor, Somatostatin

    1. Front Matter
      Pages 301-301
    2. Joseph B. Martin
      Pages 303-323
    3. Wylie Vale, Joan Vaughan, Paul Sawchenko, Hans Seifert, Louise Bilezikjian, Marilyn Perrin et al.
      Pages 325-336
    4. P. Brazeau, P. Bohlen, F. Esch, N. Ling, W. B. Wehrenberg, A. Briskin et al.
      Pages 337-346
    5. Lawrence A. Frohman, Jennifer L. Thominet, Marta Szabo
      Pages 347-360
    6. Michael O. Thorner, William S. Evans, Mary Lee Vance, Robert M. Blizzard, Alan D. Rogol, Donald L. Kaiser et al.
      Pages 361-371
    7. Geneviève Sassolas, Pierre Chatelain
      Pages 373-385
    8. Elizabeth A. Schriock, Stephen M. Rosenthal, Catherine A. Egli, David A. Harris, Berthold P. Hauffa, J. Anthony Hulse et al.
      Pages 387-403
    9. Seymour Reichlin
      Pages 405-425
  8. Chemistry of Human Growth Hormone

    1. Front Matter
      Pages 427-427
    2. Urban J. Lewis, Luciano G. Frigeri, Morton B. Sigel, Gene F. Tutwiler, Willard P. Vanderlaan
      Pages 439-447
    3. Jack L. Kostyo
      Pages 449-453
    4. James P. Hughes, Lisa L. Wheeler, Timothy J. Fields, Jeanette M. Schepper, Henry G. Friesen
      Pages 455-461
    5. David B. Donner, Kazuyo Yamada, Kenneth E. Lipson, Andrea Dorato
      Pages 463-473
    6. Wayne V. Moore, Karen Kover, Chung Ho Hung
      Pages 475-498
    7. H. Maurice Goodman, Genevieve Grichting, Vittorio Coiro
      Pages 499-512
  9. Somatomedin/Insulinlike Growth Factor

    1. Front Matter
      Pages 513-513
    2. René E. Humbel
      Pages 515-520
    3. Matthew M. Rechler, Yvonne W.-H. Yang, Jeffrey E. Terrell, Angela M. Acquaviva, Harvey J. Whitfield, Joyce A. Romanus et al.
      Pages 529-537
    4. Michael P. Czech, Cristina Mottola, Kin-Tak Yu, Yoshitomo Oka
      Pages 539-551

About this book

Introduction

It has been ten years since the National Hormone and Pituitary Program (then called the National Pituitary Agency) sponsored a symposium on human growth hormone (hGH). Numerous advances have occurred during this period. This book does not attempt to summarize past achievements. Rather, it deals with the contemporary issues in hGH research. A discussion of the present state of the art, of necessity, includes a review of the past. Some of the topics herein discussed include the following: 1. Growth hormone releasing factor (GRF). In 1973, the growth hormone inhibitory factor (somatostatin) had recently been discovered. The search for a releasing factor in humans led to its discovery not in the pituitary but in a pancreatic tumor that secreted growth hormone. The advances are discussed in this book. The current hope is that GRF will eventually become an effective therapeutic agent for idiopathic hypopituitarism in childhood and adolescence. 2. Biosynthesis of hGR by recombinant DNA technology. Current advances are discussed. Although hGH is not yet an approved drug, it will eventually become one. This will broaden our horizons in terms of hGH effectiveness in disorders other than hypopituitary dwarfism. The current experience with this type of hGH in both the Vnited States and Europe is reviewed by several authors.

Keywords

DNA G proteins biosynthesis childhood drug growth growth factor growth hormone hormone hormone therapy insulin physiology research tumor

Editors and affiliations

  • Salvatore Raiti
    • 1
  • Robert A. Tolman
    • 2
  1. 1.National Hormone and Pituitary ProgramBaltimoreUSA
  2. 2.National Institute of Arthritis, Diabetes and Digestive and Kidney DiseasesBethesdaUSA

Bibliographic information