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Anterior Pituitary Hormones

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

Much of the early research on anterior pituitary hormones was performed with extracts obtained from animal pituitary glands and with animal models for the specific analytical determination of the concentrations of anterior pituitary hormones in serum, in pituitary tissue, and in some cases by measurement of urinary excretion, for hormones which are excreted during pregnancy, for example. Biosynthetic hormone preparations are now available for human therapy, and species-specific hormone standards are also available for numerous animal species. For an understanding of the development of endocrine research, and the approach to understanding physiology that was necessary, helpful, and effective, reference is made extensively to historical methods that are no longer required. As with other fields, the receptors for hypothalamic hormones and anterior pituitary hormones have been characterized and studied, for both a better understanding of regulation and in several cases structure–activity studies. This approach has also been very helpful in understanding how the sensitivity of the pituitary gland is regulated by both negative feedback of gonadal steroids and the impact of hypothalamic hormones.

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    Jürgen Sandow

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    Franz J. Hock

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Sandow, J. (2016). Anterior Pituitary Hormones. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_81

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