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Reversal of Multidrug Resistance by Calcium Channel Blockers and Other Agents

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Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

Abstract

Calcium plays an important role in the regulation of cellular functions. Studies by Ebashi showed that calcium is involved in skeletal muscle contraction through a calcium receptor protein, troponin C, and the molecular mechanisms of muscle contraction have been elucidated (see Ebashi and Edno [1968] for a review). Rasmussen (1970) found that calcium, like cyclic AMP, is involved as a messenger in many regulatory mechanisms. Kakiuchi et al. (1970) and Cheung (1971) found that the protein calmodulin binds cellular calcium. Since then many calcium-binding proteins have been discovered, and now it is widely recognized that calcium plays important roles in mRNA transfer and regulation of cellular functions.

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Authors and Affiliations

  1. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Kami-Ikebukuro, Toshima-ku, Tokyo, 170, Japan

    Takashi Tsuruo

  2. Institute of Applied Microbiology, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113, Japan

    Takashi Tsuruo

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  1. Takashi Tsuruo
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Editors and Affiliations

  1. Department of Genetics, University of Illinois at Chicago, 60612, Chicago, Illinois, USA

    Igor B. Roninson

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Tsuruo, T. (1991). Reversal of Multidrug Resistance by Calcium Channel Blockers and Other Agents. In: Roninson, I.B. (eds) Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3794-6_19

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  • DOI: https://doi.org/10.1007/978-1-4615-3794-6_19

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