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Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

  • Igor B. Roninson

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Isolation and Properties of Multidrug-Resistant Cell Lines

    1. Front Matter
      Pages 1-1
    2. William T. Beck, Mary K. Danks
      Pages 3-55
    3. Yoshikazu Sugimoto, Takashi Tsuruo
      Pages 57-70
  3. Molecular Genetics of Multidrug Resistance

  4. Biochemical Analysis of Multidrug Resistance

    1. Front Matter
      Pages 213-213
    2. Marian B. Meyers, June L. Biedler
      Pages 243-261
    3. Noa Alon, Roger Busche, Burkhard Tümmler, John R. Riordan
      Pages 263-276
  5. P-Glycoprotein Expression in Normal and Tumor Tissues

    1. Front Matter
      Pages 277-277
    2. Michael M. Gottesman, Mark C. Willingham, Franz Thiebaut, Ira Pastan
      Pages 279-289
    3. Michael M. Gottesman, Lori J. Goldstein, Antonio Fojo, Hanan Galski, Ira Pastan
      Pages 291-301
    4. Kevin E. Noonan, Igor B. Roninson
      Pages 319-333
  6. Approaches to Reversal of Multidrug Resistance

  7. Summary

    1. Front Matter
      Pages 393-393
  8. Back Matter
    Pages 403-406

About this book

Introduction

The ability of neoplastic cells to survive exposure to various chemotherapeutic drugs represents the main obstacle to successful cancer chemotherapy. This book deals with a particular type of resistance in tumor cells that represents a single but especially important aspect of the multifaceted problem of cancer drug resistance. This type of resistance, known as multidrug or pleiotropic drug resistance, is characterized by cross-resistance of cells to several different classes of cytotoxic drugs, including some of the most commonly used anticancer agents. Over the last several years, there has been a veritable explosion of genetic, biochemical, and clinical information on multidrug resistance, which followed the identification and cloning of the genes responsible for this phenotype and the isolation of monoclonal antibodies against P-glycoproteins, the products of these genes. Elucida­ tion of the molecular mechanism of multidrug resistance has led to the formulation of novel approaches to the prediction of tumor response to chemotherapeutic drugs and increasing the efficacy of cancer therapy. Analysis of the structure and function of P­ glycoproteins from multidrug-resistant mammalian cells has also established a prototype for a novel class of eukaryotic membrane proteins, which have now been associated with a variety of transport processes in different organisms. This book summarizes the results of molecular biological, pharmacological, bio­ chemical, cytogenetic, immunological, and pathological studies on multidrug resistance in mammalian cells. Most of the chapters deal at least to some extent with the structure and expression of P-glycoprotein and its role in multidrug resistance.

Keywords

Mammalia biology cancer cancer therapy chemotherapy drug drug resistance phenotype proteins resistance tumor

Editors and affiliations

  • Igor B. Roninson
    • 1
  1. 1.Department of GeneticsUniversity of Illinois at ChicagoChicagoUSA

Bibliographic information