Abstract
The measurement of cerebral blood flow (CBF) in the clinical setting first began in earnest during the 1940s by Kety and Schmidt. By utilizing an inert diffusible gas (nitrous oxide), measuring it in arterial and jugular venous blood, and applying the Fick principle of blood flow determination they were able to calculate a global rate of CBF of mL/100 g/min. Kety–Schmidt-based CBF measurements evolved over the next 2 decades by the substitution of radioactive gases for nitrous oxide.
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Hovda, D.A., Glenn, T.C. (2014). Human Cerebral Blood Flow and Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_3
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