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Myocardial Adaptation and Autophagy

  • Dipak K. Das
  • Hannah R. Vasanthi
Chapter
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 4)

Abstract

Cells are constantly exposed to adverse environmental conditions; but they possess remarkable ability to adapt them to the stress by up-regulating their own defense system. Adaptation has been widely studied in case of heart. Myocardial adaptation to stress occurs through up-regulating many stress proteins including oxidative stress-inducible proteins, antioxidants, and heat shock proteins. Recent studies have indicated that stress adaptation, especially adaptation due to nutritional deprivation occur via autophagy, a cellular degradative mechanism involved in the recycling and turnover of cytoplasmic constituents from these cells. This review discusses the molecular link between adaptation and autophagy, and establishes the fact that myocardial adaptation to stress may occur through diverse pathways including autophagy. Accumulating evidence supports the notion that autophagy and adaptation are intimately related. Autophagy due to nutritional deprivation is a unique example of cellular adaptation. Among a number of factors, redox signaling appears to be the most important link between adaptation and autophagy. SirT-FoxO network plays a key role in both the processes. Recent studies indicate that both adaptation and autophagy are under the control of miRNA and epigenetics.

Keywords

Autophagy  Adaptation  Autophagosomes Autophagosomes Redox signaling Redox signaling Oxidative stress  Micro RNA  SirT-FoxO net work  

Notes

Acknowledgment

This study is supported by NIH HL 22559, HL 34360, and HL 33889.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Cardiovascular Research CenterUniversity of Connecticut School of MedicineFarmingtonUSA
  2. 2.Department of Biotechnology, School of Life SciencesPondicherry UniversityPondicherryIndia

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