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Myocardial Adaptation and Autophagy

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Cardiac Adaptations

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 4))

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Abstract

Cells are constantly exposed to adverse environmental conditions; but they possess remarkable ability to adapt them to the stress by up-regulating their own defense system. Adaptation has been widely studied in case of heart. Myocardial adaptation to stress occurs through up-regulating many stress proteins including oxidative stress-inducible proteins, antioxidants, and heat shock proteins. Recent studies have indicated that stress adaptation, especially adaptation due to nutritional deprivation occur via autophagy, a cellular degradative mechanism involved in the recycling and turnover of cytoplasmic constituents from these cells. This review discusses the molecular link between adaptation and autophagy, and establishes the fact that myocardial adaptation to stress may occur through diverse pathways including autophagy. Accumulating evidence supports the notion that autophagy and adaptation are intimately related. Autophagy due to nutritional deprivation is a unique example of cellular adaptation. Among a number of factors, redox signaling appears to be the most important link between adaptation and autophagy. SirT-FoxO network plays a key role in both the processes. Recent studies indicate that both adaptation and autophagy are under the control of miRNA and epigenetics.

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Acknowledgment

This study is supported by NIH HL 22559, HL 34360, and HL 33889.

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Authors and Affiliations

  1. Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT, 06030-1110, USA

    Dipak K. Das

  2. Department of Biotechnology, School of Life Sciences, Pondicherry University, Pondicherry, India

    Hannah R. Vasanthi

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  1. Dipak K. Das
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  2. Hannah R. Vasanthi
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Correspondence to Dipak K. Das .

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Editors and Affiliations

  1. Czech Republic, Institute of Physiology, Academy of Sciences of the, Videnska 1083, Prague, 142 20, Czech Republic

    Bohuslav Ostadal

  2. St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Das, D.K., Vasanthi, H.R. (2013). Myocardial Adaptation and Autophagy. In: Ostadal, B., Dhalla, N. (eds) Cardiac Adaptations. Advances in Biochemistry in Health and Disease, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5203-4_22

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