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Spindle Structure and the Mechanisms of Chromosome Movement

  • Chapter
Aneuploidy

Part of the book series: Basic Life Sciences ((BLSC,volume 36))

Abstract

The mitotic spindle is a dynamic and transient structure; it forms to segregate the duplicate chromosomes and disappears at the completion of its task. This dynamism is complex because spindle formation includes both the polymerization of fibrous components, such as microtubules, and the organization of these components into the familiar metaphase structure. The actions of the spindle fibers on chromosomes may conveniently be divided into 2 parts: an organizational phase that precedes metaphase and a segregational phase thereafter. To discuss either of these dynamic stages with clarity, it is important to have a good view of metaphase in mind. We therefore begin our discussion of chromosome movement with a description of the metaphase spindle.

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Authors and Affiliations

  1. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, 80309, USA

    J. Richard McIntosh

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  1. J. Richard McIntosh
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Editors and Affiliations

  1. U.S. Environment Protection Agency, Washington, D.C, USA

    Vicki L. Dellarco  & Peter E. Voytek  & 

  2. Council for Research Planning in Biological Sciences, Inc., Washington,D.C, USA

    Alexander Hollaender

  3. University of Alabama, Birmingham, Alabama, USA

    B. R. Brinkley

  4. New York State Department of Health, Albany, New York, USA

    Ernest B. Hook

  5. Duke University School of Medicine, Durham, North Carolina, USA

    Montrose J. Moses

  6. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

  7. M. D. Anderson Hospital and Tumor Institute, Houston, Texas, USA

    T. C. Hsu

  8. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Liane B. Russell

  9. Brookhaven National Laboratory, Upton, New York, USA

    Raymond R. Tice

  10. U.S. Environmental Protection Agency Research Triagle Park, North Carolina, USA

    Michael D. Waters

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© 1985 Plenum Press, New York

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McIntosh, J.R. (1985). Spindle Structure and the Mechanisms of Chromosome Movement. In: Dellarco, V.L., et al. Aneuploidy. Basic Life Sciences, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2127-9_14

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  • DOI: https://doi.org/10.1007/978-1-4613-2127-9_14

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