Etiology and Mechanisms

  • Vicki L. Dellarco
  • Peter E. Voytek
  • Alexander Hollaender
  • B. R. Brinkley
  • Ernest B. Hook
  • Montrose J. Moses
  • Frederick J. de Serres
  • T. C. Hsu
  • Liane B. Russell
  • Raymond R. Tice
  • Michael D. Waters

Part of the Basic Life Sciences book series (BLSC, volume 36)

Table of contents

  1. Front Matter
    Pages iii-xiv
  2. Introduction

    1. Peter E. Voytek
      Pages 1-6
  3. Human Aspects

    1. The Impact of Aneuploidy

    2. Etiological Aspects of Human Aneuploidy

      1. M. Hulten, N. Saadallah, B. M. N. Wallace, D. J. Cockburn
        Pages 75-90
      2. Renee H. Martin
        Pages 91-102
      3. Terry J. Hassold
        Pages 103-115
      4. Dorothy Warburton
        Pages 133-148
      5. Jennie Kline, Zena Stein
        Pages 149-164
    3. Neoplasia

      1. H. J. Evans
        Pages 165-178
    4. Roundtable Discussion

  4. Mechanisms Underlying Chromosome Disjunction/Nondisjunction

    1. Chromosome Movement and Distribution

    2. Meiotic Mechanisms and Their Consequences on Chromosome Distribution

  5. Current Status of Aneuploidy Testing

  6. Back Matter
    Pages 549-562

About this book


The "Symposium on Aneuploidy: Etiology and Mechanisms" was held at the Carnegie Institution of Washington Auditorium from March 25-29. 1985. This Symposium developed as a consequence of the concern of the Environmen­ tal Protection Agency with the support of the National Institute of Envi­ ronmental Health Sciences about human exposure to environmental agents that cause aneuploidy. The program was chosen to explore what is currently known about the underlying causes, the origins, and the extent of the prob­ lem of human aneuploidy, and whether exposure to environmental agents is assodated with an increased incidence of aneuploidy in humans. Basic research findings in the area of mitosis and meiosis were presented and related to possible mechanisms of how aneuploidy may be produced spontane­ ously and chemically. A survey of data regarding the chemical induction of aneuploidy in experimental organisms was presented. Outstanding scientists from different fields were invited to cover a broad perspective of aneu­ ploidy from the molecular aspects to the human situation. We hope that the publication of the proceedings will share the enthu­ siasm of the meeting and its scientific content. The topic of aneuploidy has received little attention and it is the purpose of this Volume to establish a scientific basis for assessing health risks posed by environ­ mental exposures to aneuploidy-inducing chemicals. Vicki L. DeJlarco Peter E. Voytek Alexander Hollaender vii ACKNOWLEDGEMENT The Editors of the proceedings of the "Symposium on Aneuploidy" wish to acknowledge the support of Dr. Elizabeth L.


DNA attention chromosome etiology genes health research

Editors and affiliations

  • Vicki L. Dellarco
    • 1
  • Peter E. Voytek
    • 1
  • Alexander Hollaender
    • 2
  • B. R. Brinkley
    • 3
  • Ernest B. Hook
    • 4
  • Montrose J. Moses
    • 5
  • Frederick J. de Serres
    • 6
  • T. C. Hsu
    • 7
  • Liane B. Russell
    • 8
  • Raymond R. Tice
    • 9
  • Michael D. Waters
    • 10
  1. 1.U.S. Environment Protection AgencyUSA
  2. 2.Council for Research Planning in Biological Sciences, Inc.USA
  3. 3.University of AlabamaBirminghamUSA
  4. 4.New York State Department of HealthAlbanyUSA
  5. 5.Duke University School of MedicineDurhamUSA
  6. 6.National Institute of Environmental Health SciencesUSA
  7. 7.M. D. Anderson Hospital and Tumor InstituteHoustonUSA
  8. 8.Oak Ridge National LaboratoryOak RidgeUSA
  9. 9.Brookhaven National LaboratoryUptonUSA
  10. 10.U.S. Environmental Protection Agency Research Triagle ParkUSA

Bibliographic information