Biology of the duodenal (Brunner’s) glands

  • William J. Krause
Part of the Electron Microscopy in Biology and Medicine book series (EMBM, volume 4)


The duodenal glands were first observed in 1679 by Wepfer (1) who described them during the autopsy of a beheaded woman. Wepfer described their arrangement in the duodenum and observed that when they were macerated in water, the duodenal glands discharged copious amounts of mucus. Nine years later, Brunner (2,3), who was Wepfer’s son-in-law (4), described the duodenal glands in the horse, ox, sheep, deer, dog, and beaver and presented a brief description in man. Brunner considered these glands to be accessory pancreatic tissue and termed them “glandulae duodeni” or “pancreas secundarium.” Middeldorpf (5) realized that the secretion of the duodenal glands differed from that of the pancreas and suggested that these glands be designated “the glands of Brunner.” Florey and Harding (6,7) found that the region of the duodenum containing the duodenal glands is more resistant to acid erosion than other regions of the small intestine.


Secretory Granule Vasoactive Intestinal Polypeptide Duodenal Mucosa Carbonic Anhydrase Activity Enteroendocrine Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • William J. Krause
    • 1
  1. 1.Department of AnatomySchool of Medicine, University of Missouri-ColumbiaColumbiaUSA

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