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Factitious Angiogenesis III: How to Successfully Endothelialize Artificial Cardiovascular Bioprostheses by Employing Natural Angiogenic Mechanisms

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Molecular, Cellular, and Clinical Aspects of Angiogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 285))

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Abstract

In this series of NATO ASI meetings on angiogenesis, we introduced the concept of “factitious angiogenesis” to describe a novel approach in tissue engineering aimed at the generation of permanent, hemocompatible blood conduits (31,32). We define as blood conduits a variety of cardiovascular prostheses, such as artificial vascular grafts, ventricular assist devices and total artificial hearts, and skeletal muscle ventricles. Without belaboring the profound technical and surgical problems associated with their manufacture, implantation, and/or long term use, all of these cardiovascular prostheses share a major, common obstacle: the inadequate hemocompatibility of their blood-contacting surf aces, which are made of various types of biopolymers (23,30,52). We hypothesized that the hemocompatibility in these novel blood conduits can be significantly improved by lining their blood-contacting surfaces with a non-thrombogenic monolayer of autologous endothelial cells (ECs).

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Authors and Affiliations

  1. Laboratory of Cell Biology, University of Wisconsin Medical School, Milwaukee Clinical Campus, Milwaukee, WI, 53201, USA

    Peter I. Lelkes, Victor V. Nikolaychik, Mark M. Samet & Dawn M. Wankowski

  2. Section of Cardiology, Department of Medicine, University of Wisconsin Medical School, Milwaukee Clinical Campus, Milwaukee, WI, 53201, USA

    Valerie Chekanov

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  1. Peter I. Lelkes
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  2. Victor V. Nikolaychik
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  3. Mark M. Samet
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  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

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© 1996 Plenum Press, New York

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Lelkes, P.I., Nikolaychik, V.V., Samet, M.M., Wankowski, D.M., Chekanov, V. (1996). Factitious Angiogenesis III: How to Successfully Endothelialize Artificial Cardiovascular Bioprostheses by Employing Natural Angiogenic Mechanisms. In: Maragoudakis, M.E. (eds) Molecular, Cellular, and Clinical Aspects of Angiogenesis. NATO ASI Series, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0389-3_21

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  • DOI: https://doi.org/10.1007/978-1-4613-0389-3_21

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