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"Factitious Angiogenesis": Endothelialization of Artificial Cardiovascular Prostheses

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Angiogenesis in Health and Disease

Part of the book series: NATO ASI Series ((NSSA,volume 227))

Abstract

There is an increasing demand for permanent cardiovascular prostheses, such as vascular grafts, cardiac assist devices or total artificial hearts. Currently, their longterm usage is thwarted by a number of divergent problems, such as thromboembolism, or neointimal hyperplasia. These complications can be frequently traced to inadequate hemocompatibility of the synthetic, blood contacting surfaces. This problem maybe ameliorated by factitious angiogenesis, namely the generation of nonthrombogenic, artificial blood conduits by precoating their luminal surfaces with a functional monolayer of autologous endothelial cell. In this presentation we will discuss the endothelialization of three cardiovascular prostheses: small caliber vascular grafts, artificial blood pumps, and autologous skeletal muscle ventricles.

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Author information

Authors and Affiliations

  1. Lab. Cell Biol, Univ. Wisc. Med. School, MCC, USA

    Peter I. Lelkes & Mark M. Samet

  2. Lab. Cardiovasc., Dept. Medicine, Univ. Wisc. Med. School, MCC, USA

    Carl W. Christensen

  3. Dept. Allied Health Sci., Univ. Wisc, Milwaukee, WI, USA

    David L. Amrani

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  1. Peter I. Lelkes
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  2. Mark M. Samet
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  3. Carl W. Christensen
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  4. David L. Amrani
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Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Turin Medical School, Turin, Italy

    Pietro Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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© 1992 Springer Science+Business Media New York

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Lelkes, P.I., Samet, M.M., Christensen, C.W., Amrani, D.L. (1992). "Factitious Angiogenesis": Endothelialization of Artificial Cardiovascular Prostheses. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_32

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  • DOI: https://doi.org/10.1007/978-1-4615-3358-0_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6481-8

  • Online ISBN: 978-1-4615-3358-0

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