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Molecular, Cellular, and Clinical Aspects of Angiogenesis

  • Michael E. Maragoudakis

Part of the NATO ASI Series book series (NSSA, volume 285)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Heterogeneity of Endothelial Cells

    1. Peter I. Lelkes, Vangelis G. Manolopoulos, Matthew Silverman, Shaosong Zhang, Soverin Karmiol, Brian R. Unsworth
      Pages 1-17
    2. D. S. Grant, J. L. Kinsella, H. K. Kleinman
      Pages 19-29
  3. Role of Extracellular Matrix in Angiogenesis

    1. Victor W. M. van Hinsbergh, Pieter Koolwijk, Roeland Hanemaaijer
      Pages 37-49
    2. S. K. Williamson, R. W. Rose, M. O’Hara, D. S. Grant
      Pages 51-60
  4. Angiogenic Factors and Their Receptors

    1. Anna Gualandris, Marco Rusnati, Patrizia Dell’Era, Daniela Coltrini, Elena Tanghetti, Emanuele Nelli et al.
      Pages 61-72
    2. Eliot M. Rosen, Itzhak D. Goldberg
      Pages 85-94
    3. Michael E. Maragoudakis
      Pages 95-103
    4. Luisa A. DiPietro, Peter J. Polverini
      Pages 105-113
  5. Physiological Angiogenesis

    1. Lawrence P. Reynolds, Dale A. Redmer, Anna T. Grazul-Bilska, S. Derek Killilea, R. M. Moor
      Pages 125-139
    2. O. Hudlicka, M. D. Brown, S. Egginton
      Pages 141-150
    3. James S. Constant, David Y. Suh, M. Zamirul Hussain, Thomas K. Hunt
      Pages 151-159
    4. W. Douglas Thompson, Stephen J. McNally, Naren Ganesalingam, Deirdre S. E. McCallion, Christina M. Stirk, William T. Melvin
      Pages 161-172
  6. Pathological Angiogenesis

    1. Eliot M. Rosen, Peter J. Polverini, Brian J. Nickoloff, Itzhak D. Goldberg
      Pages 181-189
    2. Timothy Hla, Ari Ristimäki, Kirsi Narko, Pazit Ben-Av, Menq-Jer Lee, Mark Evans et al.
      Pages 191-198
  7. Inhibitors of Angiogenesis

    1. Theodore Fotsis, Michael S. Pepper, Erkan Aktas, Antonia Joussen, Friedrich Kruse, Herman Adlercreutz et al.
      Pages 213-227
  8. Biotechnological Aspects of Angiogenesis

    1. Peter I. Lelkes, Victor V. Nikolaychik, Mark M. Samet, Dawn M. Wankowski, Valerie Chekanov
      Pages 229-239
    2. Robert W. Shaffer, Martin Friedlander
      Pages 241-253
  9. Back Matter
    Pages 255-298

About this book

Introduction

There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis.

Keywords

Oligosaccharid biochemistry biology biotechnology cancer cell biology development developmental biology growth molecular biology pharmacology physiology receptor research

Editors and affiliations

  • Michael E. Maragoudakis
    • 1
  1. 1.University of Patras Medical SchoolPatrasGreece

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