Abstract
An inverse correlation between geographic distribution of liver cancer incidence and the selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu province, a high liver cancer area of the People’s Republic of China. Animal experiments demonstrated that supplementation of Se reduced the incidence of liver cancer in rats exposed to anatoxin B1. Se was also shown to inhibit the growth of transplanted tumors. A lower incidence of liver preneoplastic alterations and reduction of hepatitis B virus infection in ducks by Se-supplementation was observed, and three pilot studies for a Se-intervention trial on human liver cancer were carried out on the residents of Qidong county. A protective effect on the cellular DNA damage induced by anatoxin B1 was observed in lympocytes from human with Se-supplements.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
S. Y. Yu, Y. J. Chu, X. I. Gong, C. Hou, Biol. Trace Element Res. 7, 21, 1985.
W. G. Li, S. Y. Yu, Y. J. Chu, and J. R. Xie, Chin. J. Oncol. 8, 60, 1986 (in Chinese).
W. G. Li and L. Q. Shou, Chin. J. Preventive Med. 21, 11, 1987 (in Chinese).
S. Y. Yu, L. M. Wang, and W. J. Qian, Chin. J. Oncol., 4, 50, 1982.
Q. E. Zhao, C. Z. Huang, B. Wu, and S. Y. Yu, Chin. J. Oncol. 7, 158, 1985.
L. Ding. S. Y. Yu, W. G. Li, S. D. Tan, Y. J. Chu, and N. Z. Huang, Chin. J. Oncol. (to be published).
Y. Q. Chen and W. L. Jiang, Chin. J. Infect. Disease 1, 63, 1983.
X. Chen. G. Yang, J. Chen, Z. Wen, and K. Ge, Biol. Trace Elem. Res. 2, 91, 1980.
J. Chen and L. C. Clark, J. Am. College of Toxicol. 5, 71, 1986.
F. F. Becker and S. Sell, Cancer Res. 39, 1437, 1978.
R. Kroes, G. M. Williams, and J. H. Weisburger, Cancer Res. 33, 613, 1973.
Y. Cai, L. Lao, Y. Zai, and E. Shen, Tumor 6,200, 1986 (in Chinese).
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1988 The Humana Press Inc.
About this chapter
Cite this chapter
Yu, S.Y., Chu, Y.J., Li, W.G. (1988). Selenium Chemoprevention of Liver Cancer in Animals and Possible Human Applications. In: Schrauzer, G.N. (eds) Selenium. Humana Press. https://doi.org/10.1007/978-1-4612-4606-0_18
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4606-0_18
Publisher Name: Humana Press
Print ISBN: 978-0-89603-154-8
Online ISBN: 978-1-4612-4606-0
eBook Packages: Springer Book Archive