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Intracellular Ca2+ and Insulin Action: Possible Role in the Pathogenesis of Syndrome X

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

  • 113 Accesses

Abstract

Overwhelming evidence suggests that binding to the receptor followed by receptor autophosphorylation are the initial steps by which insulin exerts its biologic effects.1-5 However, the subsequent steps in the propagation of the signal are not clear. Indeed, since the biologic effects of insulin are many, it has been suggested that more than one second messenger may be involved in the propagation of the signal.6 Intracellular Ca2+ ([Ca2+]i) may have a significant role in this regard,5 thus explaining why abnormal [Ca2+]i homeostasis may be associated with impaired insulin action7,8 or with insulin resistance.9,10

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Authors
  1. Joseph Levy
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  2. James R. Sowers
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Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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© 1994 Springer-Verlag New York, Inc.

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Levy, J., Sowers, J.R. (1994). Intracellular Ca2+ and Insulin Action: Possible Role in the Pathogenesis of Syndrome X. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_7

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_7

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