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Ion Channels and Ion Pumps

Metabolic and Endocrine Relationships in Biology and Clinical Medicine

  • Piero P. Foà
  • Mary F. Walsh

Part of the Endocrinology and Metabolism book series (EAM, volume 6)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Susan M. J. Dunn, Manjunatha B. Bhat, A. Murat Öz
    Pages 1-18
  3. Christopher M. Rembold
    Pages 137-150
  4. Angelo A. Manfredi, Maria Pia Protti, Matteo Bellone, Lucia Moiola, Bianca M. Conti-Tronconi
    Pages 151-189
  5. Tore K. Uski, Edward D. HÖgestÄtt, Karl-Erik Andersson
    Pages 190-225
  6. Peter A. Doris
    Pages 241-260
  7. Gianfranco Prestipino, Mario Nobile, Egidio Maestrone
    Pages 261-281
  8. Ralf Weik
    Pages 282-316
  9. Florenzo Battaini, Stefano Govoni, Maria Sandra Magnoni, Marco Trabucchi
    Pages 418-435
  10. Carole M. Liedtke
    Pages 500-525
  11. Anna Menini, Robert R. H. Anholt
    Pages 526-548
  12. Back Matter
    Pages 575-587

About this book

Introduction

Omnis cellula e cellula, "every cell from a cell," was dogma to the 19th­ century cellular physiologist and the cornerstone of Virchow's Cellular­ pathologie. "Spread out a cell into a layer and you will find that, in ceasing to be a cell, it has ceased to act as such," wrote the British 1 physiologist G . R. Lewes more than a century age. "The cell remains vital as long as its wall remains intact . . . " keeping its content "pure and clear" and thus preserving the "vital principle" within, echoed Claude 2 Bernard a few years later. The notion of the cell membrane as a pro­ tecting envelope held sway until it became clear that it could not account for the "coalescence" of poorly differentiated embryonic "vesicles" and for their transformation into "cell-like structures" capable of auto­ regulation and yet subject to what the grandfather of one of us defined as the "federal obligations imposed by the whole organism. ,,3 A new concept was needed, and soon the membrane was described as a structure capable of uniting as well as separating adjacent cells. Morphologic evidence for this dual function was obtained several years later when the electron microscope revealed the existence of tight and gap junc­ tions which, acting as intercellular bonds and channels, allowed the cells to communicate with one another and thus coordinate their biologic activities.

Keywords

ATP Calcium Diabetes G proteins Immunity Nucleotide cellular mechanisms homeostasis insulin insulin resistance regulation skeletal muscle smooth muscle tissue

Editors and affiliations

  • Piero P. Foà
    • 1
    • 2
  • Mary F. Walsh
    • 3
  1. 1.West BloomfieldUSA
  2. 2.Department of PhysiologyWayne State UniversityDetroitUSA
  3. 3.Section of Endocrinology,Department of Internal Medicine,School of MedicineWayne State UniversityDetroitUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-2596-6
  • Copyright Information Springer-Verlag New York 1994
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7599-2
  • Online ISBN 978-1-4612-2596-6
  • Series Print ISSN 0938-040X
  • Buy this book on publisher's site