Abstract
Colorectal cancer is a relatively common malignancy, particularly in developed countries in the western world. In the USA approximately 130 200 new cases were identified and approximately 56 300 died of their disease in 2000 [1]. In approximately 70% of patients, colorectal cancer is surgically treatable for cure. However, 30–50% eventually develop recurrence and die of their disease [2,3]. Today, physicians have at their disposal a variety of biochemical and imaging modalities to aid their efforts in detecting these recurrences while they are still potentially curable. It remains a real dilemma, both practically and economically, whether any specific test or combination of tests offers the best results. Furthermore, the optimal interval between tests is based primarily on anecdotal evidence.
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Greenlee R.T., Murray T, Bolden S, Wingo P.A. Cancer Statistics 2000. CA Cancer J Clin 2000;50:7–33.
August D, Ottow R, Sugarbaker P. Clinical perspective of human colorectal cancer metastasis. Cancer Metast Rev 1984;3:303–24.
Hughes K.S., Simon R, Songhorabodi S, et al. Resection of the liver for colorectal carcinoma metastases: a multiinstitutional study of patterns of recurrence. Surgery 1986;100:278–84.
Wangensteen O.H., Lewis F.J., Tongen T.A. The second-look in cancer surgery. Lancet 1951;ii:303–307.
Wangensteen O.H. Experience with cancer of the stomach and the colon and second look procedure. Minn Med 1968;51:1833–38.
Gilbertsen V.A., Wangensteen O.H. A summary of thirteen years’ experience with the second-look program. Surg Gynecol Obstet 1962;114:438–42.
Beart R.W. Jr, Metzger P.P., O’Connell M.J., Schutt A.J. Postoperative screening of patients with adenocarcinoma of the colon. Dis Colon Rectum 1981;24:585–88.
Tornqvist A, Ekelund G, Leondoer L. The value of intensive follow-up after curative resection for colorectal carcinoma. Br J Surg 1982;69:725–28.
Safi F, Link K.H., Beger H.G.. Is follow-up of colorectal cancer patients worthwhile? Dis Colon Rectum 1993;36:636–44.
Bohm B, Schwenk W, Hoche H.P., Stoch W. Does methodological long-term follow-up affect survival after curative resection of colorectal carcinoma? Dis Colon Rectum 1993;36:280–86.
Ohlsson B, Bieland V, Ekberg H, Graffner H, Tranberk K.G. Follow-up after curative surgery for colorectal carcinoma: randomized comparison with no follow-up. Dis Colon Rectum 1995;38:619–26.
Desch C.E., Benson A.B., Smith T.J., et al. Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology. J Clin Oncol 1999; 17: 1312–21.
Steele G. Standard postoperative monitoring of patients after primary resection of colon and rectum cancer. Cancer 1993;71:4225–35.
Vernava A.M., Longo W.E., Virgo K.S., Coplin M.A., Wade T.P., Johnson F.E. Current follow-up strategies after resection of colon cancer: results of a survey of members of the American Society of Colon and Rectal Surgeons. Dis Colon Rectum 1994;37:573–83.
Virgo K.S., Wade T.P., Longo W.E., Coplin M.A., Vernava A.M., Johnson F.E.J. Surveillance after curative colon cancer resection: practice patterns of surgical specialists. Ann Surg Oncol 1995;2:472–82.
Cooper G.S., Yuan Z, Chak A, Rimm A.A. Geographic and patient variation among Medicare beneficiaries in the use of follow-up testing after surgery for non-metastatic colorectal carcinoma. Cancer 1999;85:2124–31.
Johnson F.E., Longo W.E., Wade T.P, Coplin M.A, Vernava A.M., Virgo K.S. Practice patterns in cancer patient followup are minimally affected by surgeon age. Surg Oncol 1996;5:127–31.
Virgo K.S., Vernava A.M., Longo W.E., McKirgan L.W., Johnson F.E. Cost of patient follow-up after potentially curative colorectal cancer treatment. JAMA 1995;273:1837–41.
Johnson F.E., Longo W.E., Vernava A.M., Wade T.P., Coplin M.A., Virgo K.S.. How tumor stage affects surgeons’ surveillance strategies after colon surgery. Cancer 1995;76:1325–29.
Macintosh E.L., Rodriguez-Bigas A.R., Petrelli N.J. Colorectal carcinoma In: Johnson F.E., Virgo K.S., editors. Cancer patient followup. St Louis, MO: Mosby, 1997:118–31.
Polk H, Spratt J.S. Recurrent colorectal carcinoma: detection, treatment, and other considerations. Surgery 1971;69:9–23.
Carnovas J., Enriquez J.M., Devesa J.M., Morales V, Millan I. Value of follow-up in the management of recurrent colorectal cancer. Eur J Surg Oncol 1991;17:530–35.
Makela J, Haukipauro K, Laitinen S, Karralvoma M.I. Surgical treatment of recurrent colorectal cancer: five-year follow-up. Arch Surg 1989;124:1029–32.
Pihl E., Hughes E.S.R., McDermott F.T., Milne B.J., Price A.B. Disease-free survival and recurrence after resection of colorectal cancer. J Surg Oncol 1981;16:333–41.
Galandiuk S, Moertel C.G., Fitzgibbons R.J.J. Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surg Gynecol Obstet 1992;174:27–32.
Segall M.M., Goldberg S.M., Nivatvongs S. Abdominoperineal resection for recurrent cancer following anterior resection. Dis Colon Rectum 1980;23:359–61.
Vassilopoulos P.P., Yoon J.M., Ledesma E.J. Treatment of recurrence of adenocarcinoma of the colon and rectum at the anastomotic site. Surg Gynecol Obstet 1981;152: 777–80.
Pihl E, Hughes E.S.R., McDermott F.T. Recurrence of carcinoma of the colon and rectum at the anastomotic suture line. Surg Gynecol Obstet 1981;153:495–96.
Holm A, Bradley G, Aldrete J.S. Hepatic resection of metastases from colorectal carcinoma. Ann Surg 1989;209:428–34.
Nordlinger B, Pare R, Delva F. Hepatic resection for colorectal liver metastases: influence on survival of preoperative factors and surgery for recurrence in 80 patients. Ann Surg 1987;205:256–63.
Hughes K.S., Rosenstein R.B., Saghorabodis S. Resection of the liver for colorectal carcinoma metastases. Dis Colon Rectum 1988;31:1–4.
Goldberg R.M., Fleming T.R, Tangen C.M., et al. Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Ann Intern Med 1998;129:27–35.
Pihl E, Hughes E.S.R., McDermott F.T. Lung recurrence after curative surgery for colorectal cancer. Dis Colon Rectum 1987;30:417–19.
Beart R.W., Metzger P.P., O’Connell M.J. Postoperative screening of patients with carcinoma of the colon. Dis Colon Rectum 1981;24:585–89.
Beart R.W., O’Connell M.J. Postoperative follow-up of patients with carcinoma of the colon. Mayo Clin Proc 1983;58:361–63.
Cochran J.P., Williams J.T., Faber R.G., Slack W.W. Value of outpatient follow-up after curative surgery for carcinoma of the large bowel. BMJ 1980;280:593-95.
Decosse J.J. Early cancer detection: colorectal cancer. Cancer 1988;62: 1787–90.
Crowson M.C., Jewkes A.J., Acheson N. Haemoccult testing as an indicator of recurrent colorectal cancer: a 5-year prospective study. Eur J Oncol 1991;17:281–84.
Gilbert J.M., Jeffrey I., Evan M. Sites of recurrent tumor after curative colorectal surgery: implications of adjuvant therapy. Br J Surg 1984;71:203–205.
Gutman A.B., Olson K.B., Gutman G.B., Flood C.A. Effect of disease of the liver and biliary tract upon the phosphatase activity of serum. J Clin Invest 1940;19:129–51.
Baden H, Anderson B, Augustenborg G. Diagnostic valve of gamma-glutamyl transpeptidase and alkaline phosphatase in liver metastases. Surg Gynecol Obstet 1971;133:769–73.
Gold P, Freedman S.O. Demonstration of tumor-specific antigens in colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965;121: 439–62.
Jessup J, Thomas P. CEA: function in metastasis by human colorectal carcinoma. Cancer Metast Rev 1989;3:263–80.
Arnaud J.P., Koehl C., Adloff M. Carcinoembryonic antigen (CEA) in the diagnosis and prognosis of colorectal carcinoma. Dis Colon Rectum 1980;23:141–44.
Fletcher R.H. Carcinoembryonic antigen. Ann Intern Med 1986;104:66–73.
Hine K.R., Leonard J.C., Booth S.N., Dykes P.W. Carcinoembryonic antigen concentrations in undiagnosed patients. Lancet 1978;ii:1337–40.
Moertel C.G., Fleming T.R, MacDonald J.S., Haller D.G., Lavine T.A., Tangen C. An evaluation of carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer. JAMA 1993;270:943–47.
Bronstein R.R., Steele G, Ensminger W. The use and limitations of serial plasma carcinoembryonic antigen (CEA) levels as a monitor of changing metastatic liver tumor volume in patients receiving chemotherapy. Cancer 1980;46:266–72.
Mayer R, Garnick M, Steele G. CEA as a monitor of chemotherapy in disseminated colorectal cancer. Cancer 1978;42:1428–32.
Goslin R, Steele G, MacIntyre J. The use of preoperative plasma CEA levels for the stratification of patients after curative resection of colorectal cancers. Ann Surg 1980;192:747–51.
Hine F.R., Dyke P.W. Serum CEA testing in the postoperative surveillance of colorectal carcinoma. Br J Surg 1984;49: 689–93.
Zeng Z, Cohen A.M., Urmacher C. Usefulness of carcinoembryonic antigen monitoring despite normal preoperative valves in node-positive colon cancer patients. Dis Colon Rectum 1993;36:1063–68.
Armitage N.C., Davidson A, Tsikos D, Wood C.B. A study of the reliability of carcinoembryonic antigen blood levels in following the course of colorectal cancer. Clin Oncol 1984;10:141–47.
McCall J.L., Black R.B., Rich C.A., et al. The valve of serum carcinoembryonic antigen in predicting recurrent disease following curative resection of colorectal cancer. Dis Colon Rectum 1994;37:875–81.
Staab H.J., Anderer F.A., Stumpf E., Horning A, Fischer R, Kreninger G. Eighty-four potential second-look operations based on sequential carcinoembryonic antigen determinations and clinical investigations in patients with recurrent gastrointestinal cancer. Am J Surg 1985;149:198–204.
Carl J, Bentzen S.M., Norgaard-Pedersen B, Kronborg O. Modelling of serial carcinoembryonic antigen changes in colorectal cancer. Scand J Clin Lab Invest 1993;53:751–55.
Kievit J, van de Velde CJ. Utility and cost of carcinoembryonic antigen monitoring in colon cancer follow-up evaluation: a Markov analysis. Cancer 1990;65:2580–87.
Northover J, Houghton J, Lennon T. CEA to detect recurrence of colon cancer. JAMA 1994;272:31.
Iemura K, Moriya Y. A comparative analysis of the serum levels of NCC-ST-439, CEA and CA 19–9 in patients withcolorectal carcinoma. Eur J Surg Oncol 1993;19:439–42.
Guadagni F, Roselli M, Cosimelli M, et al. Biologic evaluation of tumor-associated glycoprotein-72 and carcinoembryonic antigen expression in colorectal cancer Part 1. Dis Colon Rectum 1994;37:S16–S23.
Fillela X., Molina R., Pique J.M., et al. Use of CA 19–9 in the early detection of recurrences in colorectal cancer: comparison with CEA. Thmour Biol 1994;15:1–6.
Graffner H, Holtberg B, Johansson B, Moller T, Peters son B.G.. Detection of recurrent cancer of the colon and rectum. J Surg Oncol 1985;28:156–59.
Reilly J.C., Rusin L.C., Theverkauf F.J. Colonoscopy: its role in cancer of the colon and rectum. Dis Colon Rectum 1982;25:532–38.
Slanetz C.A., Herter F.P., Grinell R.S. Anterior resection vs. abdominal-perineal resection for cancer of the rectum and rectosigmoid. Am J Surg 1972;123:110–17.
Rodriguez-Bigas M.A., Stulc J.P., Davidson B, Petrelli N.J. Prognostic significance of anastomotic recurrence from colorectal adenocarcinoma. Dis Colon Rectum 1992;35:838–42.
Cass A.W., Million R.R., Pfaff W.W. Patterns of recurrence following surgery alone for adenocarcinoma of the colon and rectum. Cancer 1976;37:2861–65.
Thoeni R.F., Menuck C. Comparison of barium enema and colonoscopy in detection of small colonic polyps. Radiology 1977;124:631–35.
Barkin J., Cohen M., Flaxman M. Value of routine follow-up endoscopy for the detection of recurrent colorectal carcinoma. Am J Gastroenterol1988;88: 1355-60.
Moss A.A., Thoeni R.F., Schnyder P. Valve of computed tomography in the detection and staging of recurrent rectal carcinomas. J Comput Assist Tomogr 1981;5:870–74.
Kelvin F.M., Korobkin M, Heaston D.K. The pelvis after surgery for rectal carcinoma: serial CT observations with emphasis on non-neoplastic features. AJR Am J Roentgenol 1983;141:959–64.
DeLange E.E., Fechner R.E., Wanebo H.J. Suspected recurrent rectosigmoid carcinoma after abdominoperineal resection: MR imaging and histopathologic findings. Radiology 1989;170:323–28.
Rifkin M.D., Ehrlich S.M., Marks G. Staging of rectal carcinoma: prospective comparison of endorectal US and CT. Radiology 1989;170:319–22.
Goldenberg D.M., DeLand E, Kim E. Use of radiolabeled antibodies to carcinoembryonic antigen in the detection and localization of diverse cancers by external photoscanning. N Engl J Med 1978;298:1384–88.
Holting T, Schlag P, Steinbacher M, Kretzschmar U. The value of immunoscintigraphy for the operative retreatment of colorectal cancer. Cancer 1989;64:830–33.
Goldenberg D.M., Larson S.M. Radioimmunodetection in cancer identification. J Nucl Med 1992;33:803–14.
Abdel-Nabi H, Doerr R.J. Clinical applications of indium-111-labeled monoclonal antibody imaging in colorectal cancer patients. Semin Nucl Med 1993;23:99–113.
Rutgers E.J.T. Radioimmunotargeting in colorectal carcinoma. Eur J Cancer 1995;31A:1243–47.
Flanagan F.L., Dehdashti F, Ogunbigi O.A., Kodner I.J., Siegel B.A. Utility of FDG-PET for investigating unexplained plasma CEA elevation in patients with colorectal cancer. Ann Surg 1998;227:319–23.
Keogan M.T., Lowe V.J., Baker M.E., McDermott V.G., Lyerly H.K., Coleman R.E. Local recurrence of rectal cancer: evaluation with F-18 fluorodeoxyglucose PET imaging. Abdom Imaging 1997;22:332–37.
Schreve R.H., Terpstra O.T., Ausema L., Lameris J.S., Van Seijen A.J., Jeckel J. Detection of liver metastases: a prospective study comparing ultrasonography and computed tomography. Br J Surg 1984;71:947–49.
Steele G, Bleday R, Meyer R.J., Linblad A, Petrelli N, Weaver D. A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584. J Clin Oncol 1991;9: 1105–12.
Ward B.A., Miller D.L., Frank J.A. Prospective evaluation of hepatic imaging studies in the detection of colorectal metastases: correlation with surgical findings. Surgery 1989;105:180–87.
Bernadino M., Ervin B, Steinberg H. Delayed hepatic CT scanning: increased confidence and improved detection of hepatic metastases. Radiology 1986;159:71–74.
Abdel-Nabi H.H., Schwartz A.N., Goldfogel G. Colorectal tumors: scintigraphy with In-111 anti-CEA monoclonal antibody and correlation with surgical histopathologic and immunohistochemical findings. Radiology 1988; 166:744–52.
Vitola J.V., Delbehe D, Sandler M.P., et al. Positron emission tomography to stage suspected metastatic colorectal carcinoma to the liver. Am J Surg 1996;171:21–26.
Gupta N.C., Bowman B.M., Frank A.L. PET FDG imaging for follow-up evaluation of treated colorectal cancer [abstract]. Radiology 1991;199:181P.
Strauss L.G., Clorius J.H., Schlag P. Recurrence of colorectal tumors: PET evaluation. Radiology 1989;170:329–32.
Howell J.D., Wotherspoon H, Leen E, Cooke T.C., McArdle C.S. Evaluation of a follow-up programme after curative resection for colorectal cancer. Br J Cancer 1999;79:308–10.
Okmura S, Kondo H, Tsuboi M, et al. Pulmonary resection for metastatic colorectal cancer: experiences with 159 patients. J Thorac Cardiovasc Surg 1996;112:867–74.
Robinson B.J., Rice T.W., Strong S.W., Rybicki L.A., Blackstone E.H. Is resection of pulmonary and hepatic metastaseswarranted in patients with colorectal cancer? J Thorac Cardiovasc Surg 1999;117:66–75.
Murata S, Moriya Y, Akasu T, Fujita S, Sugihara K. Resection of both hepatic and pulmonary metastases in patients with colorectal carcinoma. Cancer 1998;83:1086–93.
Kamiyoshihara M, Hirai T, Kawashima O, Morishita Y. Resection of pulmonary metastases in six patients with disease free interval greater than 10 years. Ann Thorac Surg 1998;66:231–33.
Regnard J.F., Gruenwald D, Spaggiari L, et al. Surgical treatment of hepatic and pulmonary metastases from colorectal cancers. Ann Thorac Surg 1998:66:214–18.
Ambiru S, Miyazaki M, Ito H, et al. Resection of hepatic and pulmonary metastases in patients with colorectal carcinoma. Cancer 1998;82:274–78.
Zanella A, Marchet A, Mainente P, Nitti D, Lise M. Resection of pulmonary metastases from colorectal carcinoma. Eur J Surg Oncol 1997;23:424–27.
Vigneswaran W.T. Management of pulmonary metastases from colorectal cancer. Semin Surg Oncol 1996;12:264–66.
Baron O, Amini M, Deveau D, Despins P, Sagan C.A., Michaud J.L. Surgical resection of pulmonary metastases from colorectal carcinoma. Five year survival and main prognostic factors. Eur J Cardiothorac Surg 1996;10:347–51.
Girard P, Ducreux M, Baldeyrou P, et al. Surgery for lung metastases from colorectal cancer: analysis of prognostic factors. J Clin Oncol 1996;14:2047–53.
Posner J.B., Chernik N.L. Intracranial metastases from systemic cancer. Adv Neurol 1978;19:579–92.
Alden T.D., Gianino J.W., Saclarides T.J. Brain metastases from colorectal cancer. Dis Colon Rectum 1996;39:541–45.
Zimm S, Wampler G.L., Stablein D, Hazra T, Young H.F. Intracerebral metastases in solid tumor patients: natural history and results of treatment. Cancer 1981;48:384–94.
Sundaresan N, Galicich J.H. Surgical treatment of brain metastases: clinical and computerized tomography evaluation of the results of treatment. Cancer 1985;55: 1382–88.
Cascino T.L., Leavengood J.M., Kemeny N, Posner J.B. Brain metastases from colon cancer. J Neurooncol 1983;1:203–209.
Cairncross J.G., Kim J.H., Posner J.B. Radiation therapy for brain metastases. Ann Neurol 1980;7:529–41.
Smalley S.R., Laws E.R., O’Fallon J.R., Shaw E.G., Schray M.F. Resection of solitary brain metastases: role of adjuvant radiation and prognostic variables in 229 patients. J Neurosurg 1992;77:531–40.
Farnell G.F., Buckner J.C., Cascino T.L., O’Connell M.J., Schomberg P.J., Suman V. Brain metastases from colorectal carcinoma. The long term survivors. Cancer 1996;78:711–16.
Besbeas S., Stearns M.W. Jr. Osseous metastases from carcinoma of the colon and rectum. Dis Colon Rectum 1978;21:266–68.
Bonnheim D.C., Petrelli N.J., Herrera L., Walsh D., Mittleman A. Osseous metastases from colorectal carcinoma. Am J Surg 1986;151:457–59.
Masgagni D, Corbellini L, Urciuoloi P, Di Matteo G. Endoluminal ultrasound for early detection of local recurrence of rectal cancer. Br J Surg 1989;76: 1176–80.
Bruinvels D.J., Stiggelbout A.M., Kievit J, Van Houwelingen H, Habbema D.F., Van de Velde C. Follow-up of patients with colorectal cancer: a meta-analysis. Ann Surg 1994;219: 174–82.
Kjeldsen B, Kronberg O, Fenger C, Jorgensen O. A prospective randomized study of follow-up after radical surgery for colorectal cancer. Br J Surg 1997;84:666–69.
Makela J.T., Laitnen S.O., Kairaluoma M.I. Five year follow-up after radical surgery for colorectal cancer: results of a prospective randomized trial. Arch Surg 1995;130:1062–67.
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Nadig, D.E., Virgo, K.S., Longo, W.E., Johnson, F.E. (2001). Follow-up After Potentially Curative Therapy for Rectal Cancer. In: Audisio, R.A., Geraghty, J.G., Longo, W.E. (eds) Modern Management of Cancer of the Rectum. Springer, London. https://doi.org/10.1007/978-1-4471-0331-8_12
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