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Translational Research on Nicotine Dependence

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Translational Neuropsychopharmacology

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 28))

Abstract

Nicotine dependence is a chronic, relapsing disorder with complex biological mechanisms underlying the motivational basis for this behavior. Although more than 70 % of current smokers express a desire to quit, most relapse within one year, underscoring the need for novel treatments. A key focus of translational research models addressing nicotine dependence has been on cross-validation of human and animal models in order to improve the predictive value of medication screening paradigms. In this chapter, we review several lines of research highlighting the utility of cross-validation models in elucidating the biological underpinnings of nicotine reward and reinforcement, identifying factors which may influence individual response to treatment, and facilitating rapid translation of findings to practice.

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Authors and Affiliations

  1. Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Mary Falcone & Caryn Lerman

  2. Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Bridgin Lee & Julie A. Blendy

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  1. Mary Falcone
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  2. Bridgin Lee
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  4. Julie A. Blendy
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Correspondence to Caryn Lerman .

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  1. University of Cambridge, Cambridge, UK

    Trevor W. Robbins

  2. University of Cambridge, Cambridge, UK

    Barbara J. Sahakian

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Falcone, M., Lee, B., Lerman, C., Blendy, J.A. (2015). Translational Research on Nicotine Dependence. In: Robbins, T.W., Sahakian, B.J. (eds) Translational Neuropsychopharmacology. Current Topics in Behavioral Neurosciences, vol 28. Springer, Cham. https://doi.org/10.1007/7854_2015_5005

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