Mesenchymal Stem Cell Therapy for Osteoarthritis: Practice and Possible Promises

Nasiri, Nahid; Nateghi, Reihaneh; Zarei, Fatemeh; Hosseini, Samaneh; Eslaminejad, Mohamdreza Baghaban

doi:10.1007/5584_2021_695

Nahid Nasiri^8,9,
Reihaneh Nateghi⁹,
Fatemeh Zarei⁸,
Samaneh Hosseini^8,10 &
…
Mohamdreza Baghaban Eslaminejad⁸

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1387))

681 Accesses
3 Citations

Abstract

Osteoarthritis (OA) is a common progressively degenerative joint disease that affects more than 300 million people worldwide. OA is manifested by articular cartilage degradation, chronic pain, deformity, functional disability, and decreased quality of life. A real challenge in OA management is the lack of an effective cure because exiting therapeutics often provide symptom control rather than disease modification; therefore, they fail to prevent disease progression. The inadequate treatments for OA management have encouraged researchers to study mesenchymal stem cells (MSCs) as an investigational treatment for OA. MSCs are a promising tool for OA because of their availability; expand cultivation and multi-lineage differentiation capacity as well as well-documented paracrine function have made MSCs a promising tool in this field. Accordingly, MSCs application has been successfully utilized in a broad range of pre-clinical OA animal models as well as clinical studies with the aim of cartilage repair which had not previously been achieved using classical treatments. Here, the brief scientific review of MSC role in the control of OA as well as the proposed mechanisms are discussed. We provide an insight into the last 10 years’ studies conducted on preclinical and clinical OA treatment as well as future opportunities in OA management strategies employing MSCs.

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Abbreviations

3D:: Three-dimensional
ACI:: Autologous chondrocyte implantation
ACLT:: Anterior cruciate ligament amputation
ADMSCs:: Adipose-derived mesenchymal stem cells
BMSCs:: Bone marrow mesenchymal stem cells
CDMP1:: Cartilage-derived morphogenetic protein 1
CTGF:: Connective tissue growth factor
CXCR4:: C-X-C chemokine receptor 4
ECM:: Extracellular matrix
EGF:: Epidermal growth factor
ESWT:: Extracorporeal shockwave therapy
FGF:: Fibroblast growth factor
FGFR:: Fibroblast growth factor receptor
GAG:: Glycosaminoglycan
GO:: Graphene oxide
HA:: Hyaluronic acid
IA:: Intra-articular
IGF-1:: Insulin-like growth factor 1
IV:: Intravenous
KOOS:: Knee Injury and Osteoarthritis Outcome Score
MIA:: Monosodium iodoacetate
MRI:: Magnetic resonance imaging
MSCs:: Mesenchymal stem cells
NPs:: Nanoparticles
OA:: Osteoarthritis
PBS:: Phosphate-buffered saline
PGE2:: Prostaglandin E2
PLMSCs:: Placenta-derived mesenchymal stem cells
PRP:: Platelet-rich plasma
TGFβ:: Transforming growth factor beta
UCMSCs:: Umbilical cord mesenchymal stem cells
VAS:: Visual analog scale
VEGF1:: Vascular endothelial growth factor1
WJMSCs:: Wharton’s jelly mesenchymal stem cells
WOMAC:: Western Ontario and McMaster Universities Osteoarthritis Index
μCT:: Micro-CT

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Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Nahid Nasiri, Fatemeh Zarei, Samaneh Hosseini & Mohamdreza Baghaban Eslaminejad
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Nahid Nasiri & Reihaneh Nateghi
Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Samaneh Hosseini

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Nahid Nasiri
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Reihaneh Nateghi
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Fatemeh Zarei
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Samaneh Hosseini
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Mohamdreza Baghaban Eslaminejad
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Correspondence to Samaneh Hosseini or Mohamdreza Baghaban Eslaminejad .

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(emeritus) Ottawa Hospital Research Institute, Ottawa, ON, Canada
Kursad Turksen

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Nasiri, N., Nateghi, R., Zarei, F., Hosseini, S., Eslaminejad, M.B. (2021). Mesenchymal Stem Cell Therapy for Osteoarthritis: Practice and Possible Promises. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 16. Advances in Experimental Medicine and Biology(), vol 1387. Springer, Cham. https://doi.org/10.1007/5584_2021_695

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Published: 04 January 2022
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