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Biomedical Applications of Electrospun Piezoelectric Nanofibrous Scaffolds

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Electrospun Polymeric Nanofibers

Part of the book series: Advances in Polymer Science ((POLYMER,volume 291))

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Abstract

The recent developments in the field of smart biomaterials and the research related to their properties have provided ground-breaking approaches to the field of biomedical research. Piezoelectric materials are one of the most promising smart materials for biomedical applications which can generate electric signals when mechanically stimulated. Electrospun nanofibers are an exciting class of materials for biomedical applications due to their topological and mechanical properties which can directly relate to the characteristics of biological materials and extracellular matrices. Electrospinning technology can be evoked to create micro-nano-size fibres and scaffolds with various in situ functionalities such as piezoelectricity which can be directly accessible to the cellular level and hence makes it a versatile tool for bioengineering applications. Electrospinning itself can be used to evoke piezoelectricity in certain polymers and hence the combination of electrospinning and piezoelectricity can be a better option for the development of the next generation of smart biomaterials. The chapter gives a technical overview of the properties and the applications of piezoelectric nanofibers and their potential applications in tissue engineering to implantable self-powered biomedical devices.

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References

  1. Wang LY, Zhu BH, Huang JB, Xiang X, Tang YJ, Ma L (2020) Ultrasound-targeted microbubble destruction augmented synergistic therapy of rheumatoid arthritis via targeted liposomes. J Mater Chem B 8:5245–5256

    Article  CAS  Google Scholar 

  2. Jin Y, Shahriari D, Jeon EJ, Park S, Choi YS, Back J (2021) Functional skeletal muscle regeneration with thermally drawn porous fibers and reprogrammed muscle progenitors for volumetric muscle injury. Adv Mater 33

    Google Scholar 

  3. Xue JJ, Wu T, Qiu JC, Rutledge S, Tanes ML, Xia YN (2020) Promoting cell migration and neurite extension along uniaxially aligned nanofibers with biomacromolecular particles in a density gradient. Adv Funct Mater 30

    Google Scholar 

  4. Xue JJ, Wu T, Dai YQ, Xia YN (2019) Electrospinning and electrospun nanofibers: methods, materials, and applications. Chem Rev 119:5298–5415

    Article  CAS  Google Scholar 

  5. Rezk AI, Unnithan AR, Park CH, Kim CS (2018) Rational design of bone extracellular matrix mimicking tri-layered composite nanofibers for bone tissue regeneration. Chem Eng J 350:812–823

    Article  CAS  Google Scholar 

  6. Sasikala ARK, Unnithan AR, Thomas RG, Ko SW, Jeong YY, Park CH (2018) Multifaceted implantable anticancer device for potential postsurgical breast cancer treatment: a single platform for synergistic inhibition of local regional breast cancer recurrence, surveillance, and healthy breast reconstruction. Adv Funct Mater 28

    Google Scholar 

  7. Unnithan AR, Sasikala ARK, Park CH, Kim CS (2017) Electrospun polyurethane nanofibrous mats for wound dressing applications. Polyurethane Polym:233–246

    Google Scholar 

  8. Guo BL, Ma PX (2018) Conducting polymers for tissue engineering. Biomacromolecules 19:1764–1782

    Article  CAS  Google Scholar 

  9. Koppes AN, Seggio AM, Thompson DM (2011) Neurite outgrowth is significantly increased by the simultaneous presentation of Schwann cells and moderate exogenous electric fields. J Neural Eng 8

    Google Scholar 

  10. Chiang MC, Robinson KR, Vanable JW (1992) Electrical fields in the vicinity of epithelial wounds in the isolated bovine eye. Exp Eye Res 54:999–1003

    Article  CAS  Google Scholar 

  11. Kim JI, Hwang TI, Lee JC, Park CH, Kim CS (2020) Regulating electrical cue and mechanotransduction in topological gradient structure modulated piezoelectric scaffolds to predict neural cell response. Adv Funct Mater 30

    Google Scholar 

  12. Mokhtari F, Azimi B, Salehi M, Hashemikia S, Danti S (2021) Recent advances of polymer-based piezoelectric composites for biomedical applications. J Mech Behav Biomed 122

    Google Scholar 

  13. Cartmell SH, Thurstan S, Gittings JP, Griffiths S, Bowen CR, Turner IG (2014) Polarization of porous hydroxyapatite scaffolds: influence on osteoblast cell proliferation and extracellular matrix production. J Biomed Mater Res A 102:1047–1052

    Article  CAS  Google Scholar 

  14. Zhang XH, Zhang CG, Lin YH, Hu PH, Shen Y, Wang K (2016) Nanocomposite membranes enhance bone regeneration through restoring physiological electric microenvironment. ACS Nano 10:7279–7286

    Article  CAS  Google Scholar 

  15. Kim M, Kaliannagounder VK, Unnithan AR, Park CH, Kim CS, Sasikala ARK (2020) Development of in-situ poled nanofiber based flexible piezoelectric nanogenerators for self-powered motion monitoring. Appl Sci 10

    Google Scholar 

  16. Sasikala ARK, Kaliannagounder VK, Alluri NR, Shrestha BK, Kim SJ, Ali-Boucetta H (2022) Development of self-powered multifunctional piezomagnetic nanoparticles for non-invasive post-surgical osteosarcoma theranogeneration. Nano Energy 96

    Google Scholar 

  17. Motamedi AS, Mirzadeh H, Hajiesmaeilbaigi F, Bagheri-Khoulenjani S, Shokrgozar MA (2017) Effect of electrospinning parameters on morphological properties of PVDF nanofibrous scaffolds. Prog Biomater 6:113–123

    Article  CAS  Google Scholar 

  18. Damaraju SM, Wu SL, Jaffe M, Arinzeh TL (2013) Structural changes in PVDF fibers due to electrospinning and its effect on biological function. Biomed Mater:8

    Google Scholar 

  19. Kitsara M, Blanquer A, Murillo G, Humblot V, Vieira SD, Nogues C (2019) Permanently hydrophilic, piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical stimulation on osteoblasts. Nanoscale 11:8906–8917

    Article  CAS  Google Scholar 

  20. Damaraju SM, Shen YY, Elele E, Khusid B, Eshghinejad A, Li JY (2017) Three-dimensional piezoelectric fibrous scaffolds selectively promote mesenchymal stem cell differentiation. Biomaterials 149:51–62

    Article  CAS  Google Scholar 

  21. Li YC, Liao CZ, Tjong SC (2019) Electrospun polyvinylidene fluoride-based fibrous scaffolds with piezoelectric characteristics for bone and neural tissue engineering. Nanomaterials (Basel):9

    Google Scholar 

  22. Bar-Cohen Y (2006) Biomimetics using electroactive polymers (EAP) as artificial muscles – a review. J Adv Mater Covina 38:3–9

    CAS  Google Scholar 

  23. Martins PM, Ribeiro S, Ribeiro C, Sencadas V, Gomes AC, Gama FM (2013) Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering. RSC Adv 3:17938–17944

    Article  CAS  Google Scholar 

  24. Hitscherich P, Wu SL, Gordan R, Xie LH, Arinzeh T, Lee EJ (2016) The effect of PVDF-TrFE scaffolds on stem cell derived cardiovascular cells. Biotechnol Bioeng 113:1577–1585

    Article  CAS  Google Scholar 

  25. Augustine R, Dan P, Sosnik A, Kalarikkal N, Tran N, Vincent B (2017) Electrospun poly(vinylidene fluoride-trifluoroethylene)/zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation. Nano Res 10:3358–3376

    Article  CAS  Google Scholar 

  26. Gouveia PJ, Rosa S, Ricotti L, Abecasis B, Almeida HV, Monteiro L (2017) Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes. Biomaterials 139:213–228

    Article  CAS  Google Scholar 

  27. Liu Z, Zhang S, Jin YM, Ouyang H, Zou Y, Wang XX (2017) Flexible piezoelectric nanogenerator in wearable self-powered active sensor for respiration and healthcare monitoring. Semicond Sci Tech 32

    Google Scholar 

  28. Yu JB, Hou XJ, He J, Cui M, Wang C, Geng WP (2020) Ultra-flexible and high-sensitive triboelectric nanogenerator as electronic skin for self-powered human physiological signal monitoring. Nano Energy 69

    Google Scholar 

  29. Yang T, Pan H, Tian G, Zhang BB, Xiong D, Gao YY (2020) Hierarchically structured PVDF/ZnO core-shell nanofibers for self-powered physiological monitoring electronics. Nano Energy 72

    Google Scholar 

  30. Yang Y, Pan H, Xie GZ, Jiang YD, Chen CX, Su YJ (2020) Flexible piezoelectric pressure sensor based on polydopamine-modified BaTiO3/PVDF composite film for human motion monitoring. Sensor Actuat A Phys 301

    Google Scholar 

  31. Deng WL, Yang T, Jin L, Yan C, Huang HC, Chu X (2019) Cowpea-structured PVDF/ZnO nanofibers based flexible self-powered piezoelectric bending motion sensor towards remote control of gestures. Nano Energy 55:516–525

    Article  CAS  Google Scholar 

  32. Park S, Guan XY, Kim Y, Creighton FX, Wei E, Kymissis I (2018) PVDF-based piezoelectric microphone for sound detection inside the cochlea: toward totally implantable cochlear implants. Trends Hear 22

    Google Scholar 

  33. Zhuang YY, Xu Z, Li F, Liao ZP, Liu WH (2015) Improve piezoelectricity and elasticity of Ce-doped BaTiO3 nanofibers – towards energy harvesting application. RSC Adv 5:55269–55276

    Article  CAS  Google Scholar 

  34. Fang J, Niu HT, Wang HX, Wang XG, Lin T (2013) Enhanced mechanical energy harvesting using needleless electrospun poly(vinylidene fluoride) nanofibre webs. Energ Environ Sci 6:2196–2202

    Article  CAS  Google Scholar 

  35. Maity K, Garain S, Henkel K, Schmeisser D, Mandal D (2020) Self-powered human-health monitoring through aligned PVDF nanofibers interfaced skin-interactive piezoelectric sensor. ACS Appl Polym Mater 2:862–878

    Article  Google Scholar 

  36. Shin YE, Lee JE, Park Y, Hwang SH, Chae HG, Ko H (2018) Sewing machine stitching of polyvinylidene fluoride fibers: programmable textile patterns for wearable triboelectric sensors. J Mater Chem A 6:22879–22888

    Article  CAS  Google Scholar 

  37. Kumari S, Sahu SS, Gupta B, Mishra SK (2020) Energy harvesting via human body activities. Adv Ubiquit Sens App 8:87–106

    Google Scholar 

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Authors and Affiliations

  1. Faculty of Life Sciences, Centre for Pharmaceutical Engineering Science, School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK

    Afeesh Rajan Unnithan & Arathyram Ramachandra Kurup Sasikala

Authors
  1. Afeesh Rajan Unnithan
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  2. Arathyram Ramachandra Kurup Sasikala
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Correspondence to Afeesh Rajan Unnithan .

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Editors and Affiliations

  1. Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (University), Kochi, India

    R. Jayakumar

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Unnithan, A.R., Sasikala, A.R.K. (2023). Biomedical Applications of Electrospun Piezoelectric Nanofibrous Scaffolds. In: Jayakumar, R. (eds) Electrospun Polymeric Nanofibers. Advances in Polymer Science, vol 291. Springer, Cham. https://doi.org/10.1007/12_2023_144

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