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References
Sonnleitner B (2000) Instrumentation of biotechnological processes. Adv Biochem Eng/Biotechnol 66:1–64
Schuegerl K (2001) Progress in monitoring, modeling and control of bioprocesses during the last 20 years. J Biotechnol 85(2):149–173
Carloni A, Turner APF (2011) Bioprocess monitoring. Encycl Ind Biotechnol 2:766–783
Junker BH, Wang HY (2006) Bioprocess monitoring and computer control: key roots of the current PAT initiative. Biotechnol Bioeng 95(2):226–261
Duennebier G, Tups H (2007) FDA PAT Initiative—Eine Anwendersicht zu technischen Möglichkeiten und aktueller industrieller Umsetzung. Chem Ing Tech 79(12):2019–2028
Clementschitsch F, Bayer K (2006) Improvement of bioprocess monitoring: development of novel concepts. Microb Cell Fact 5:19
Julien C, Whitford W (2007) Bioreactor monitoring, modeling, and simulation. BioProc Int 5(1):10–17
Glassey J, Gernaey KV, Clemens C, Schulz TW, Oliveira R, Striedner G, Mandenius CF (2011) Process analytical technology (PAT) for biopharmaceuticals. Biotechnol J 6:369–377
Vojinovic V, Cabral JMS, Fonseca LP (2006) Real-time bioprocess monitoring. Part I: in situ sensors. Sens Actuator B 114(2):1083–1091
Olsson L, Schulze U, Nielsen J (1998) On-line bioprocess monitoring—an academic discipline or an industrial tool? Trends Anal Chem 17(2):88–95
Kell DB, Sonnleitner B (1995) GMP—good modelling practice. Trends Biotechnol 13:481–492
Cimander C, Bachinger T, Mandenius CF (2003) Integration of distributed multi-analyzer monitoring and control in bioprocessing based on a real-time expert system. J Biotechnol 103(3):237–248
Cimander C, Mandenius CF (2002) Online monitoring of a bioprocess based on a multi-analyser system and multivariate statistical process modelling. J Chem Technol Biotechnol 77(10):1157–1168
Harms P, Kostov Y, Rao G (2002) Bioprocess monitoring. Curr Opin Biotechnol 13(2):124–127
Badugu R, Kostov Y, Rao G, Tolosa L (2008) Development and application of an excitation ratio metric optical pH sensor for bioprocess monitoring. Biotechnol Prog 24(6):1393–1401
Kermis HR, Kostov Y, Harms P, Rao G (2002) Dual excitation ratiometric fluorescent pH sensor for noninvasive bioprocess monitoring: development and application. Biotechnol Prog 18(5):1047–1053
Schenk J, Marison IW, von Stockar U (2008) pH prediction and control in bioprocesses using mid-infrared spectroscopy. Biotechnol Bioeng 100(1):82–93
Kjaergaard L (1977) The redox potential: its use and control in biotechnology. Adv Biochem Eng 7:131–150
Funke M, Diederichs S, Kensy F, Mueller C, Buechs J (2009) The baffled microtiter plate: increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol Bioeng 103(6):1118–1128
Henes B, Sonnleitner B (2007) Controlled fed-batch by tracking the maximal culture capacity. J Biotechnol 132(2):118–126
Lam H, Kostov Y (2009) Optical instrumentation for bioprocess monitoring. Adv Biochem Eng/Biotechnol 116:1–28
Ge X, Kostov Y, Rao G (2005) Low-cost noninvasive optical CO2 sensing system for fermentation and cell culture. Biotechnol Bioeng 89(3):329–334
Granstedt F (2005) Modelling of an electroacoustic gas sensor. Sens Actuat B 104(2):308–311
Custer TG, Wagner WP, Kato S, Bierbaum VM, Fall R (2003) Potential of on-line CIMS for bioprocess monitoring. Biotechnol Prog 19(4):1355–1364
Pollard D, Christensen J (2010) Vent gas analysis. Encycl Ind Biotechnol 7:4759–4773
Madrid RE, Felice CJ (2005) Microbial biomass estimation. Crit Rev Biotechnol 25(3):97–112
Ansorge S, Esteban G, Schmid G (2010) On-line monitoring of responses to nutrient feed additions by multi-frequency permittivity measurements in fed-batch cultivations of CHO cells. Cytotechnology 62(2):121–132
Sarrafzadeh MH, Belloy L, Esteban G, Navarro JM, Ghommidh C (2005) Dielectric monitoring of growth and sporulation of Bacillus thuringiensis. Biotechnol Lett 27(7):511–517
Sarrafzadeh MH, Guiraud JP, Lagneau C, Gaven B, Carron A, Navarro JM (2005) Growth, sporulation, delta-endotoxins synthesis, and toxicity during culture of Bacillus thuringiensis H14. Curr Microbiol 51(2):75–81
Maskow T, Roellich A, Fetzer I, Ackermann JU, Harms H (2008) On-line monitoring of lipid storage in yeasts using impedance spectroscopy. J Biotechnol 135(1):64–70
Markx GH, Davey CL, Kell DB (1991) The permittistat: a novel type of turbidostat. J Gen Microbiol 137:735–743
Bluma A, Hoepfner T, Lindner P, Rehbock C, Beutel S, Riechers D, Hitzmann B, Scheper T (2010) In-situ imaging sensors for bioprocess monitoring: state of the art. Anal Bioanal Chem 398(6):2429–2438
Hoepfner T, Bluma A, Rudolph G, Lindner P, Scheper T (2010) A review of non-invasive optical-based image analysis systems for continuous bioprocess monitoring. Bioproc Biosys Eng 33(2):247–256
Rudolph G, Brueckerhoff T, Bluma A, Korb G, Scheper T (2007) Optische Inline-Messverfahren zur Zellzahl- und Zellgroessenbestimmung in der Bioprozesstechnik. Chem Ing Tech 79(1–2):42–51
Ulber R, Frerichs JG, Beutel S (2003) Optical sensor systems for bioprocess monitoring. Anal Bioanal Chem 376(3):342–348
Prediger A, Bluma A, Hoepfner T, Lindner P, Beutel S, Mueller J, Hilterhaus L, Liese A, Scheper T (2011) In-situ-Mikroskopie zur Online-Ueberwachung von Enzymtraegern und Zweiphasenprozessen. Chem Ing Tech 83(6):884–887
Zhao R, Natarajan A, Srienc F (1999) A flow injection flow cytometry system for on-line monitoring of bioreactors. Biotechnol Bioeng 62(5):609–617
Abu-Absi NR, Zamamiri A, Kacmar J, Balogh SJ, Srienc F (2003) Automated flow cytometry for acquisition of time-dependent population data. Cytometry Part A 51(A):87–96
Sitton G, Srienc F (2008) Mammalian cell culture scale-up and fed-batch control using automated flow cytometry. J Biotechnol 135(2):174–180
Sitton G, Srienc F (2008) Growth dynamics of mammalian cells monitored with automated cell cycle staining and flow cytometry. Cytometry Part A 73(A):538–545
Birou B, Marison IW, von Stockar U (1987) Calorimetric investigation of aerobic fermentations. Biotechnol Bioeng 30(5):650–660
von Stockar U, Birou B (1989) The heat generated by yeast cultures with a mixed metabolism in the transition between respiration and fermentation. Biotechnol Bioeng 34(1):86–101
Schubert T, Breuer U, Harms H, Maskow T (2007) Calorimetric bioprocess monitoring by small modifications to a standard bench-scale bioreactor. J Biotechnol 130(1):24–31
Sivaprakasam S, Schuler MM, Hama A, Hughes KM, Marison IW (2011) Biocalorimetry as a process analytical technology process analyser; robust in-line monitoring and control of aerobic fed-batch cultures of crabtree-negative yeast cells. J Therm Anal Calorim 104(1):75–85
Voisard D, Pugeaud P, Kumar AR, Jenny K, Jayaraman K, Marison IW, von Stockar U (2002) Development of a large-scale biocalorimeter to monitor and control bioprocesses. Biotechnol Bioeng 80(2):125–138
von Stockar U, Marison IW (1989) The use of calorimetry in biotechnology. Adv Biochem Eng/Biotechnol 40:93–136
Dabros M, Amrhein M, Bonvin D, Marison IW, von Stockar U (2009) Data reconciliation of concentration estimates from mid-infrared and dielectric spectral measurements for improved on-line monitoring of bioprocesses. Biotechnol Prog 25(2):578–588
Staerk E, Hitzmann B, Schuegerl K, Scheper T, Fuchs C, Koester D, Maerkl H (2002) A useful tool for non-invasive bioprocess monitoring. Adv Biochem Eng/Biotechnol 74:21–38
Anton F, Lindemann C, Hitzmann B, Reardon KF, Scheper T (2010) Fluorescence techniques for bioprocess monitoring. Encycl Ind Biotechnol 4:2482–2491
Reischer H, Schotola I, Striedner G, Poetschacher F, Bayer K (2004) Evaluation of the GFP signal and its aptitude for novel on-line monitoring strategies of recombinant fermentation processes. J Biotechnol 108(2):115–125
Broger T, Odermatt RP, Ledergerber P, Sonnleitner B (2009) Exploiting fluorescent reporter molecules for process analytical technology (PAT). Chimia 63(3):171–173
Skibsted E, Lindemann C, Roca C, Olsson L (2001) On-line bioprocess monitoring with a multi-wavelength fluorescence sensor using multivariate calibration. J Biotechnol 88(1):47–57
Haack MB, Eliasson A, Olsson L (2004) On-line cell mass monitoring of Saccharomyces cerevisiae cultivations by multi-wavelength fluorescence. J Biotechnol 114(1–2):199–208
Harbeck C, Hitzmann B, Lindemann C, Sosnitza P, Faurie R, Scheper T (2001) Verwendung der 2D-Fluoreszenzspektroskopie zur On-line-Ueberwachung der chromatographischen Melasseentzuckerung. Chem Ing Tech 73(7):861–864
Derfus GE, Abramzon D, Tung M, Chang D, Kiss R, Amanullah A (2009) Cell culture monitoring via an auto-sampler and an integrated multi-functional off-line analyzer. Biotechnol Prog 26(1):284–292
Martens S, Borchert SO, Faber BW, Cornelissen G, Luttmann R (2011) Fully automated production of potential malaria vaccines with Pichia pastoris in integrated processing. Eng Life Sci 11(4):429–435
Gastrock G, Lemke K, Metze J (2001) Sampling and monitoring in bioprocessing using microtechniques. J Biotechnol 82(2):123–135
Broger T, Odermatt RP, Huber P, Sonnleitner B (2011) Real-time on-line flow cytometry for bioprocess monitoring. J Biotechnol 154:240–247
Hewitt CJ, Nebe-von-Caron G (2004) The application of multi-parameter flow cytometry to monitor individual microbial cell physiological state. Adv Biochem Eng/Biotechnol 89:197–223
Straeuber H, Mueller S (2010) Viability states of bacteria—specific mechanisms of selected probes. Cytometry Part A 77(7):623–634
Mueller S, Nebe-von-Caron G (2010) Functional single-cell analyses: flow cytometry and cell sorting of microbial populations and communities. FEMS Microbiol Rev 34:554–587
Lopes da Silva T, Piekova L, Mileu J, Roseiro JC (2009) A comparative study using the dual staining flow cytometric protocol applied to Lactobacillus rhamnosus and Bacillus licheniformis batch cultures. Enzyme Microb Technol 45(2):134–138
Freimark D, Jerome V, Freitag R (2010) A GFP-based method facilitates clonal selection of transfected CHO cells. Biotechnol J 5(1):24–31
Muench T, Sonnleitner B, Fiechter A (1992) New insights into the synchronization mechanism with forced synchronous cultures of Saccharomyces cerevisiae. J Biotechnol 24:299–314
Fritsch M, Starruss J, Loesche A, Mueller S, Bley T (2005) Cell cycle synchronization of Cupriavidus necator by continuous phasing measured via flow cytometry. Biotechnol Bioeng 92(5):635–642
Marx A, Hewitt CJ, Grewal R, Scheer S, Vandre K, Pfefferle W, Kossmann B, Ottersbach P, Beimfohr C, Snaidr J, Auge C, Reuss M (2003) Anwendungen der Zytometrie in der Biotechnologie. Chem Ing Tech 75(5):608–614
Diaz M, Herrero M, Garcia LA, Quiros C (2010) Application of flow cytometry to industrial microbial bioprocesses. Biochem Eng J 48(3):385–407
Langwost B, Kresbach GM, Scheper T, Ehrat M, Widmer HM (1995) Field-flow fractionation—an analytical tool for many applications. Eur Congr Biotechnol 7 (Nice, F: poster)
Hawe A, Friess W, Sutter M, Jiskoot W (2008) Online fluorescent dye detection method for the characterization of immunoglobulin G aggregation by size exclusion chromatography and asymmetrical flow field flow fractionation. Anal Biochem 378(2):115–122
Baker KN, Rendall MH, Patel A, Boyd P, Hoare M, Freedman RB, James DC (2002) Rapid monitoring of recombinant protein products: a comparison of current technologies. Trends Biotechnol 20(4):149–156
Cha HJ, Dalal NG, Bentley WE (2004) In vivo monitoring of intracellular expression of human interleukin-2 using green fluorescent protein fusion partner in Pichia pastoris. Biotechnol Lett 26(14):1157–1162
Kaiser C, Pototzki T, Ellert A, Luttmann R (2008) Applications of PAT—process analytical technology in recombinant protein processes with Escherichia coli. Eng Life Sci 8(2):132–138
Peckham GD, Bugos RC, Su WW (2006) Purification of GFP fusion proteins from transgenic plant cell cultures. Protein Expr Purif 49(2):183–189
Zhuang R, Zhang Y, Zhang R, Song C, Yang K, Yang A, Jin B (2008) Purification of GFP fusion proteins with high purity and yield by monoclonal antibody-coupled affinity column chromatography. Protein Expr Purif 59(1):138–143
Ruzicka J, Hansen EH (1981) Flow injection analysis. Wiley, New York
Rehbock C, Beutel S, Brueckerhoff T, Hitzmann B, Riechers D, Rudolph G, Stahl F, Scheper T, Friehs K (2008) Bioprozessanalytik. Chem Ing Tech 80(3):267–286
Endres C, Haake C, Landgrebe D, Beutel S, Stahl F, Hitzmann B, Scheper T, Friehs K (2009) Moderne Bioprozessanalytik—eine kurze Uebersicht. Biospektrum 15(6):662–664
Vojinovic V, Cabral JMS, Fonseca L (2007) Ex situ bioprocess monitoring techniques. Chem Ind Chem Eng Q 13(2):103–116
Almeida C (2004) Flow injection analysis system for on-line cutinase activity assay. Anal Chim Acta 502(1):115–124
Bracewell D, Gill A, Hoare M (2002) An in-line flow injection optical biosensor for real-time bioprocess monitoring. Food Bioprod Proc 80(2):71–77
Haouz A, Stieg S (2002) Continuous monitoring of d-glucose and L-lactate by flow injection analysis. Enzyme Microb Technol 30(1):129–133
Nandakumar MP, Palsson E, Gustavsson PE, Larsson PO, Mattiasson B (2000) Superporous agarose monoliths as mini-reactors in flow injection systems. On-line monitoring of metabolites and intracellular enzymes in microbial cultivation processes. Bioseparation 9(4):193–202
Horstkotte B, Arnau C, Valero F, Elsholz O, Cerda V (2008) Monitoring of sorbitol in Pichia pastoris cultivation applying sequential injection analysis. Biochem Eng J 42(1):77–83
Sohn OJ, Kim CK, Rhee JI (2008) Immobilization of glucose oxidase and lactate dehydrogenase onto magnetic nanoparticles for bioprocess monitoring system. Biotechnol Bioproc Eng 13(6):716–723
Lili W, Jie Q, Zhongce H, Yuguo Z, Wei H (2006) Determination of dihydroxyacetone and glycerol in fermentation broth by pyrolytic methylation/gas chromatography. Anal Chim Acta 557(1–2):262–266
Fricke J, Pohlmann K, Tatge F, Lang F, Faber B, Luttmann R (2011) A multi-bioreactor system for optimal production of malaria vaccines with Pichia pastoris. Biotechnol J 6(4):437–451
Tohmola N, Ahtinen J, Pitkaenen JP, Parviainen V, Joenvaeaerae S, Hautamaeki M, Lindroos P, Maekinen J, Renkonen R (2011) On-line high performance liquid chromatography measurements of extracellular metabolites in an aerobic batch yeast (Saccharomyces cerevisiae) culture. Biotechnol Bioproc Eng 16(2):264–272
Warth B, Rajkai G, Mandenius CF (2010) Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein. J Biotechnol 147(1):37–45
Cos O, Ramon R, Montesinos JL, Valero F (2006) Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: a review. Microb Cell Fact 5:17
Plum A, Rehorek A (2005) Strategies for continuous on-line high performance liquid chromatography coupled with diode array detection and electrospray tandem mass spectrometry for process monitoring of sulfonated azo dyes and their intermediates in anaerobic-aerobic bioreactors. J Chrom A 1084(1–2):119–133
Buettgenbach S, Michalzik M, Wilke R (2006) New approaches to online bioprocess monitoring. Eng Life Sci 6(5):449–454
Kulp M, Vassiljeva I, Vilu R, Kaljurand M (2002) Monitoring of the degradation of phenols by Rhodococcus bacteria by using micellar electrokinetic chromatography. J Separat Sci 25(15–17):1129–1135
Ehala S, Vassiljeva I, Kuldvee R, Vilu R, Kaljurand M (2001) On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms. Fresenius J Anal Chem 371(2):168–173
Tahkoniemi H, Helmja K, Menert A, Kaljurand M (2006) Fermentation reactor coupled with capillary electrophoresis for on-line bioprocess monitoring. J Pharm Biomed Anal 41(5):1585–1591
Yang TH, Wittmann C, Heinzle E (2006) Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry. Metabol Eng 8(5):417–431
Yang TH, Wittmann C, Heinzle E (2006) Respirometric 13C flux analysis—Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum. Metabol Eng 8(5):432–446
Dorfner R, Ferge T, Yeretzian C, Kettrup A, Zimmermann R (2004) Laser mass spectrometry as on-line sensor for industrial process analysis: process control of coffee roasting. Anal Chem 76(5):1386–1402
Biasioli F, Gasperi F, Yeretzian C, Maerk TD (2011) PTR-MS monitoring of VOCs and BVOCs in food science and technology. Trends Anal Chem 30(7):968–977
Feng HT, Wong NSC, Sim LC, Wati L, Ho Y, Lee MM (2010) Rapid characterization of high/low producer CHO cells using matrix-assisted laser desorption/ionization time-of-flight. Rap Comm Mass Spectrom 24:1226–1230
Wiss J, Zilian A (2003) Online spectroscopic investigations (FTIR/Raman) of industrial reactions: synthesis of tributyltin azide and hydrogenation of chloronitrobenzene. Org Process Res Dev 7(6):1059–1066
Wiss J, Laenzlinger M, Wermuth M (2005) Safety improvement of a Grignard reaction using on-line NIR monitoring. Org Process Res Dev 9(2):365–371
Burgbacher J, Wiss J (2008) Industrial applications of online monitoring of drying processes of drug substances using NIR. Org Process Res Dev 12(2):235–242
Vaidyanathan S, White S, Harvey LM, McNeil B (2003) Influence of morphology on the near-infrared spectra of mycelial biomass and its implications in bioprocess monitoring. Biotechnol Bioeng 82(6):715–724
Schenk J, Marison IW, von Stockar U (2007) Simplified Fourier-transform mid-infrared spectroscopy calibration based on a spectra library for the on-line monitoring of bioprocesses. Anal Chim Acta 591(1):132–140
Scarff M, Arnold SA, Harvey LM, McNeil B (2006) Near infrared spectroscopy for bioprocess monitoring and control: current status and future trends. Crit Rev Biotechnol 26(1):17–39
Roychoudhury P, Harvey LM, McNeil B (2006) The potential of mid infrared spectroscopy (MIRS) for real time bioprocess monitoring. Anal Chim Acta 571(2):159–166
Rhiel M, Ducommun P, Bolzonella I, Marison I, von Stockar U (2002) Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements. Biotechnol Bioeng 77(2):174–185
Arnold SA, Crowley J, Woods N, Harvey LM, McNeil B (2003) In-situ near infrared spectroscopy to monitor key analytes in mammalian cell cultivation. Biotechnol Bioeng 84(1):13–19
Vaidyanathan S, Arnold A, Matheson L, Mohan P, Macaloney G, McNeil B, Harvey LM (2000) Critical evaluation of models developed for monitoring an industrial submerged bioprocess for antibiotic production using near-infrared spectroscopy. Biotechnol Prog 16(6):1098–1105
McGovern AC, Broadhurst D, Taylor J, Kaderbhai N, Winson MK, Small DA, Rowland JJ, Kell DB, Goodacre R (2002) Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production. Biotechnol Bioeng 78(5):527–538
Lee H (2004) In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy. Vibrat Spectrosc 35(1–2):131–137
Landgrebe D, Haake C, Hoepfner T, Beutel S, Hitzmann B, Scheper T, Rhiel M, Reardon KF (2010) On-line infrared spectroscopy for bioprocess monitoring. Appl Microbiol Biotechnol 88(1):11–22
Jarute G, Kainz A, Schroll G, Baena JR, Lendl B (2004) On-line determination of the intracellular poly (β-hydroxybutyric acid) content in transformed Escherichia coli and glucose during PHB production using stopped-flow attenuated total reflection FT-IR spectrometry. Anal Chem 76(21):6353–6358
Kansiz M, Gapes JR, McNaughton D, Lendl B, Schuster KC (2001) Mid-infrared spectroscopy coupled to sequential injection analysis for the on-line monitoring of the acetone-butanol fermentation process. Anal Chim Acta 438(1–2):175–186
Bilitewski U (2005) Biosensors for bioprocess monitoring. Compr Anal Chem XLIV:539–578
Vojinovic V, Bertin L, Cabral JMS, Fonseca LP (2006) Horseradish peroxidase combined with oxidase enzymes a valuable bioanalytical tool: lactate oxidase—a case study. Eng Life Sci 6(2):181–186
Vojinovic V, Esteves F, Cabral J, Fonseca L (2006) Bienzymatic analytical microreactors for glucose, lactate, ethanol, galactose and L-amino acid monitoring in cell culture media. Anal Chim Acta 565(2):240–249
Katrlik J, Vostiar I, Sefcovicova J, Tkac J, Mastihuba V, Valach M, Stefuca V, Gemeiner P (2007) A novel microbial biosensor based on cells of Gluconobacter oxydans for the selective determination of 1,3-propanediol in the presence of glycerol and its application to bioprocess monitoring. Anal Bioanal Chem 388(1):287–295
Bachinger T, Riese U, Eriksson RK, Mandenius CF (2000) Electronic nose for estimation of product concentration in mammalian cell cultivation. Bioproc Eng 23(6):637–642
Bachinger T, Mandenius CF, Striedner G, Clementschitsch F, Durrschmid E, Cserjan-Puschmann M, Doblhoff-Dier O, Bayer K (2001) Non-invasive detection of the metabolic burden on recombinant microorganisms during fermentation processes. J Chem Technol Biotechnol 76(8):885–889
Clemente JJ, Monteiro SMS, Carrondo MJT, Cunha AE (2008) Predicting sporulation events in a bioreactor using an electronic nose. Biotechnol Bioeng 101(3):545–552
Buczkowska A, Witkowska E, Gorski L, Zamojska A, Szewczyk, Krzysztof W, Wroblewski W, Ciosek P (2010) The monitoring of methane fermentation in sequencing batch bioreactor with flow-through array of miniaturized solid state electrodes. Talanta 81(4–5):1387–1392
Soederstroem C, Rudnitskaya A, Legin A, Krantz-Ruelcker C (2005) Differentiation of four Aspergillus species and one Zygosaccharomyces with two electronic tongues based on different measurement techniques. J Biotechnol 119(3):300–308
Schmidt J, Mueller U, Wallimann C, Mathes S, Probst C, Andretta C, Leist C, Graf-Hausner U (2008) Monitoring ATP status in the metabolism of production cell lines. BioProc Int 6:46–54
Szmacinski H, Smith DS, Hanson MA, Kostov Y, Lakowicz JR, Rao G (2008) A novel method for monitoring monoclonal antibody production during cell culture. Biotechnol Bioeng 100(3):448–457
Becker T, Hitzmann B, Muffler K, Poertner R, Reardon KF, Stahl F, Ulber R (2007) Future aspects of bioprocess monitoring. Adv Biochem Eng/Biotechnol 105:249–293
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Sonnleitner, B. (2012). Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy. In: Mandenius, CF., Titchener-Hooker, N. (eds) Measurement, Monitoring, Modelling and Control of Bioprocesses. Advances in Biochemical Engineering/Biotechnology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_173
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