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In-Situ-Fluorescence-Probes: A Useful Tool for Non-invasive Bioprocess Monitoring

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Tools and Applications of Biochemical Engineering Science

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 74))

Abstract

Optical sensors appear to be very promising for different applications in modern biotechnology. They offer the possibility to interface all the well known optical analysis techniques to bioprocesses via fiber optical cables. Thus, high sophisticated and sensitive optical analysis techniques can be coupled to a bioprocess via these light signal transporting fibers. A wide variety of sensor types for application in biotechnology has been described [1-4]. Normally these sensors are non-invasive and the response times are nearly instantaneous. In particular, the use of glass fiber technology makes these sensors small, robust and reduces their costs.

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References

  1. Wolfbeis OS (1991) Fiber optic chemical sensors and biosensors. CRC Press, Boca Raton

    Google Scholar 

  2. Bittner C, Wehnert G, Scheper T (1998) Biotechnol Bioeng 60(1):23–35

    Article  Google Scholar 

  3. Scheper T, Hitzmann B, Stärk E, Ulber R, Faurie R, Sosnitza P, Reardon KF (1999) Bioanalytics: detailed insight into bioprocesses, Anal Chim Acta 400:121–143

    Article  CAS  Google Scholar 

  4. Marose S, Lindemann C, Ulber R, Scheper T (1999) TIBTECH 17:30–34

    CAS  Google Scholar 

  5. Vaneous RD (1978) Understanding nephelometric instrumentation, Am Lab 6:38–46

    Google Scholar 

  6. Hancher CW, Thacker LH, Phares EF (1974) Biotechnol Bioeng 16:475–484

    Article  CAS  Google Scholar 

  7. Koch AL (1970) Anal Biochem 252–259

    Google Scholar 

  8. Lee C, Lim H (1980) Biotechnol Bioeng 22:639–642

    Article  Google Scholar 

  9. Lee YH (1981) Biotechnol Bioeng 23:1903–1906

    Article  Google Scholar 

  10. Lima Filho JL, Lendingham WM (1987) Biotechnol Tech 1:145–150

    Google Scholar 

  11. Kamiyama N, Oikawa Y (1979) Biotechnol Bioeng Symp 9:103–116

    Google Scholar 

  12. Metz H (1981) Chem Tech 10:691–696

    Google Scholar 

  13. Merten O-W, Palfi GE, Steiner J (1986) Adv Biotechnol 6:111–178

    CAS  Google Scholar 

  14. Steiner J (1987) Dev Biol Stand 66:357–360

    Google Scholar 

  15. Junker BH, Reddy J, Gbewonyo K, Greasham R (1994) Bioprocess Eng 10:95–207

    Google Scholar 

  16. Wu P, Ozturk SS, Blackie JD, Thrift JC, Figueroa C, Naveh D (1995) Biotechnol Bioeng 45:495–502

    Article  CAS  Google Scholar 

  17. Konstantinov K, Chuppa S, Sajan E, Tsai Y, Yoon S, Golim F (1994) Trends Biotechnol 12:324–333

    Article  CAS  Google Scholar 

  18. Hatch RT, Veilleux BA (1995) Biotechnol Bioeng 46:371–374

    Article  CAS  Google Scholar 

  19. Kisalita WS (1994) Biotechnol Tech 8:747–750

    Article  Google Scholar 

  20. Niamimohasses R, Barnett DM, Green DA, Smith PR (1995) Meas Sci Technol 6:1291–1300

    Article  Google Scholar 

  21. Klimant I, Wolfbeis OS (1995) Anal Chem 67:3160–3173

    Article  CAS  Google Scholar 

  22. Wolfbeis OS (1991) Fiber optic chemical sensors and biosensors, vols 1 and 2. CRC Press, Boca Raton, FL

    Google Scholar 

  23. Weigl BH, Holobar A, Trettnak W, Klimant I, Kraus H, O'Leary P, Wolfbeis OS (1994) J Biotechnol 32:127–138

    Article  CAS  Google Scholar 

  24. Chung H, Arnold MA, Rhiel M, Murhammer DW (1995) Appl Biochem Biotechnol 50:109–125

    Article  CAS  Google Scholar 

  25. Freitag R (1993) Appl Biosens 4:75–79

    CAS  Google Scholar 

  26. Watts HJ, Yeung D, Parkes H (1995) Anal Chem 76:4283–4289

    Article  Google Scholar 

  27. Chang YH, Chang TC, Kao E-F, Chou C (1996) Biosci Biotechnol Biochem 60:1571–1574

    Article  CAS  Google Scholar 

  28. Chung H, Arnold MA, Rhiel M, Murhammer DW (1995) Appl Biochem Biotechnol 50:109–125

    Article  CAS  Google Scholar 

  29. Chung H, Arnold MA, Rhiel M, Murhammer DW (1996) Appl Spectros 50:270–276

    Article  CAS  Google Scholar 

  30. Riley MR, Rhiel M, Zhou X, Arnold MA, Murhammer DW (1997) Biotechnol Bioeng 55:11–15

    Article  CAS  Google Scholar 

  31. Zhou X, Chung H, Arnold MA, Rhiel M, Murhammer DW (1995) In: Rogers KR, Mulchandani A, Zhou W (eds) Biosensor and chemical sensor technology. American Chemical Society, Washington, DC

    Google Scholar 

  32. Rhiel M, Ziegler T, Ducommun P, von Stockar U, Marison IW (1999) Proceedings of the 16th ESACT Meeting, Lugano, Switzerland, pp 207–209

    Google Scholar 

  33. Ducommun P, Bolzonella I, Rhiel M, Pugeaud P, von Stockar U, Marison IW (2001) On-line determination of animal cell concentration. Biotech. Bioeng 72:515–522

    Article  CAS  Google Scholar 

  34. Cavinato AG, Mayes DM, Ge Z, Callis JB (1990) Anal Chem 62:1977–1982

    Article  CAS  Google Scholar 

  35. Macalony G, Draper I, Preston J, Anderson KB, Rollins MJ (1996) Food Bioprod Process 71:212–220

    Article  Google Scholar 

  36. Vaccari G, Dosi E, Campi AI, Gonzalez-Vara RA, Matteuzzi D, Montovani G (1994) Biotechnol Bioeng 43:913–917

    Article  CAS  Google Scholar 

  37. Eberl R, Wilke J (1996) Sens Actuat B 32:203–208

    Article  Google Scholar 

  38. Srivinas SP, Mutharasan R (1987) Biotechnol Bioeng 30(6):769–774

    Article  Google Scholar 

  39. Srivinas SP, Mutharasan R (1987) Biotechnol Lett 9(2): 139–142

    Article  Google Scholar 

  40. Scheper T, Reardon KF (1991) In: Göpel WG, Hesse JH, Memel JN (eds) Sensors in biotechnology, sensors, vol 2. VCH, Weinheim, pp 1024–1046

    Google Scholar 

  41. Schügerl K, Lindemann C, Marose S, Scheper T (1998) In: Berovic M (ed) Bioprocess Engineering Course, 27 Sep–2 Oct 1998, Brac, Croatia. National Institute of Chemistry, Supetar, pp 400–415

    Google Scholar 

  42. Marose S, Lindemann C, Scheper T (1998) Biotechnol Prog 14:63–74

    Article  CAS  Google Scholar 

  43. Duysens LNM, Amesz J (1957) Biochim Biophys Acta 24:19–26

    Article  CAS  Google Scholar 

  44. Harrison DEF, Chance B (1970) Appl Microbiol 19(3):446–450

    CAS  Google Scholar 

  45. Zabriskie DW, Humphrey AE (1978) Eur J Appl Microbiol 35(2):337–343

    CAS  Google Scholar 

  46. Zabriskie DW, Armiger WB, Humphrey AE (1975) Proc ASM Meeting, New York, p 195

    Google Scholar 

  47. Beyeler W, Einsele A, Fiechter A (1981) Eur J Appl Microbiol Biotechnol 13:10–14

    Article  CAS  Google Scholar 

  48. Beyeler W, Gschwend K, Fiechter A (1983) In-situ Fluorometrie: Chem Ing Tech 55(5):869–871

    CAS  Google Scholar 

  49. Scheper T, Schügerl K (1986) J Biotechnol 3:221–229

    Article  CAS  Google Scholar 

  50. Meyer C, Beyeler W (1984) Biotechnol Bioeng 26:916–925

    Article  CAS  Google Scholar 

  51. Siano SA, Mutharasan R (1989) Biotechnol Bioeng 34:660–670

    Article  CAS  Google Scholar 

  52. Peck MW, Chynoweth DP (1990) Biotechnol Lett 12:17–22

    Article  CAS  Google Scholar 

  53. Siano SA, Mutharasan R (1991) Biotechnol Bioeng 37:141–159

    Article  CAS  Google Scholar 

  54. Srivastava AK, Volesky B (1991) Appl Microbiol Biotechnol 34:450–457

    Article  CAS  Google Scholar 

  55. Kwong SCW, Rao G (1994) Biotechnol Bioeng 44:453–459

    Article  CAS  Google Scholar 

  56. Nielsen J, Johansen CL, Villadsen J (1994) J Biotechnol 38:51–62

    Article  CAS  Google Scholar 

  57. Boyer PM, Humphrey AE (1988) Biotechnol Lett 2(3): 193–198

    CAS  Google Scholar 

  58. Samson R, Beaumier D, Beaulieu C (1987) J Biotechnol 6:175–190

    Article  CAS  Google Scholar 

  59. Gerl K (1986) J Biotechnol 3:231–238

    Article  Google Scholar 

  60. Gerl K (1986) Ann NY Acad Sci 506:431–445

    Google Scholar 

  61. Heinzle E, Goldschmidt B, Moes J, Dunn IJ (1986) Proc 5th Yugoslavian-Austrian-Italian Chem Eng Conf, Portoroz, Yugoslavia, pp 525–534

    Google Scholar 

  62. Groom CA, Luong JHT, Mulchandani A (1988) J Biotechnol 8:271–278

    Article  CAS  Google Scholar 

  63. Meyer HP, Beyeler W, Fiechter A (1984) J Biotechnol 1(5/6):341–349

    Article  Google Scholar 

  64. Scheper T, Gebauer A, Schügerl K (1987) Chem Eng J 34:B7–B12

    Article  CAS  Google Scholar 

  65. Gebauer A, Scheper T, Schügerl K (1987) Bioprocess Eng 2:13–23

    Article  Google Scholar 

  66. Li J-K, Humphrey AE (1991) Biotechnol Bioeng 37:1043–1049

    Article  CAS  Google Scholar 

  67. Li J-K, Asali EC, Humphrey AE (1991) Am Chem Soc Eng 21–27

    Google Scholar 

  68. Li J-K, Humphrey AE (1992) J Fermentat Bioeng 74:104–111

    Article  CAS  Google Scholar 

  69. Horvath JJ, Glazier SA, Spangler CJ (1993) Biotech Prog 9:666–670

    Article  CAS  Google Scholar 

  70. Lipton AJ, Domach MM (1992) Biotechnol Bioeng 39:13–19

    Article  CAS  Google Scholar 

  71. Tartakovsky B, Sheintuch M (1996) Biotechnol Prog 12:126–135

    Article  CAS  Google Scholar 

  72. Walker CC, Dhurjati P (1989) Biotechnol Bioeng 33:500–505

    Article  CAS  Google Scholar 

  73. Armiger WB, Lee JF, Montalvo LM, Forro JR (1985) Proc 190th ACS Meeting, Chicago, MBTD 40

    Google Scholar 

  74. Zabriskie DW (1979) Biotechnol Bioeng Symp 9:117–123

    Google Scholar 

  75. Scheper T, Schügerl K (1986) Appl Microbiol Biotechnol 23:440–444

    Article  CAS  Google Scholar 

  76. Watteeuw C, Armiger WB, Ristroph D, Humphrey AE (1979) Biotechnol Bioeng 21:1221–1237

    Article  CAS  Google Scholar 

  77. Scheper T, Wehnert G, Schügerl K (1997) DECHEMA Biotechnology Conferences, vol 1, pp 63–66

    Google Scholar 

  78. Luong JHT, Carrier DJ (1986) Appl Microbiol Biotechnol 24:65–70

    Article  CAS  Google Scholar 

  79. Forro JR, Maenner GF, Armiger WB (1984) Proc 188th ACS National Meeting, Philadelphia, MBTD 79

    Google Scholar 

  80. Leist C, Meyer HP, Fiechter A (1986) J Biotechnol 4, 235–246

    Article  CAS  Google Scholar 

  81. MacMichael G, Armiger WB, Lee JF, Mutharasan R (1987) Biotechnol Tech 1:213–218

    Article  Google Scholar 

  82. Müller W, Wehnert G, Scheper T (1988) Anal Chim Acta 213:47–53

    Article  Google Scholar 

  83. Maneshin SK, Arevshatyan AA (1972) Appl Biochem Microbiol 8:273–275

    Google Scholar 

  84. Einsele A, Ristroph DL, Humphrey AE (1979) Eur J Appl Microbiol Biotechnol 6:335–339

    Article  CAS  Google Scholar 

  85. Li J, Humphrey AE (1989) Biotechnol Lett11(3):177–182

    Article  CAS  Google Scholar 

  86. Betz A, Chance B (1965) Arch Biochem Biophys 109:579–584

    Article  CAS  Google Scholar 

  87. Chance B, Estabrook RW, Gosh A (1964) Natl Acad Sci USA 51:1244–1251

    Article  CAS  Google Scholar 

  88. Doran PM, Bailey JE (1987) Biotechnol Bioeng 29:892–897

    Article  CAS  Google Scholar 

  89. Reardon KF, Scheper T, Bailey JE (1986) Biotechnol Lett 8(11):817–822

    Article  CAS  Google Scholar 

  90. Reardon KF, Scheper T, Bailey JE (1987) Biotechnol Progr 3(3):153–167

    Article  CAS  Google Scholar 

  91. Rao G, Mutharasan R (1989) Appl Microbiol Biotechnol 30:59–66

    CAS  Google Scholar 

  92. Ulber R, Faurie R, Sosnitza P, Fischer L, Stärk E, Harbeck C, Scheper T (2000) J Chromatogr A 882:329–334

    Article  CAS  Google Scholar 

  93. Stärk E, Harbeck C, Faurie R, Lindemann C, Scheper T, Proceedings of SPIE, 10 Sept 1999, Boston, Massachusetts, USA, pp 42–48

    Google Scholar 

  94. Riesenberg D, Guthke R (1999) Appl Microbiol Biotechnol 51:422–430

    Article  CAS  Google Scholar 

  95. Lee YL, Blanch HW (1993) Biotechnol Bioeng 46:579–587

    Google Scholar 

  96. Suzuki T, Yamane T, Shimizu S (1987) Appl Microbiol Biotechnol 25:526–531

    Article  CAS  Google Scholar 

  97. Riesenberg D (1991) Curr Opin Biotechnol 34:380–384

    Article  Google Scholar 

  98. Kleman GL, Strohl WR (1994) Curr Opin Biotechnol 5:180–186

    Article  CAS  Google Scholar 

  99. Lee L, Blanch HW (1993) Biotechnol Bioeng 41:781–790

    Article  Google Scholar 

  100. Lee SY (1996) Trends Biotechnol 14:98–105

    Article  CAS  Google Scholar 

  101. Winter J, Neubauer P, Glockshuber R, Rudolph R (2000) J Biotechnol 84(2):175–185

    Article  CAS  Google Scholar 

  102. Märkl H, Lechner M, Götz F (1990) J Fermentat Bioeng 69(4):244–249

    Article  Google Scholar 

  103. Pörtner R, Märkl H (1998) Appl Microbiol Biotechnol 50:403–414

    Article  Google Scholar 

  104. Ogbonna JC, Märkl H (1993) Biotechnol Bioeng 41:1092–1100

    Article  CAS  Google Scholar 

  105. Nakano K, Rischke M, Sato S, Märkl H (1997) Appl Microbiol Biotechnol 48:597–601

    Article  CAS  Google Scholar 

  106. Hitzmann B, Pekelev T, Marose S, Lindemann C, Scheper T (1998), Conference in Osaka. Elsevier Science, Oxford, pp 451–456

    Google Scholar 

  107. Michelon LE, Kelleher WJ (1963) Lloydia 26:192–201

    CAS  Google Scholar 

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Dedicated to Prof. Dr. Wolf-Dieter Deckwer on the occasion of his 60th birthday

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Stärk, E. et al. (2002). In-Situ-Fluorescence-Probes: A Useful Tool for Non-invasive Bioprocess Monitoring. In: Schügerl, K., et al. Tools and Applications of Biochemical Engineering Science. Advances in Biochemical Engineering/Biotechnology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45736-4_2

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  • DOI: https://doi.org/10.1007/3-540-45736-4_2

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