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Human Apolipoprotein A-IV

  • Conference paper
Human Apolipoprotein Mutants III

Part of the book series: NATO ASI Series ((ASIH,volume 73))

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Abstract

Human apolipoprotein A-IV is a 376 amino acid glycoprotein with a molecular weight of 46,000 Daltons, synthesized predominantly in the small intestine (Weisgraber 1978; Beisiegel 1979; Green 1979; Utermann 1979; Green 1980; Weinberg 1983; Karathanasis 1986; Elshourbagy 1986; Gordon 1984). ApoA-IV is found in plasma and lymph mainly unassociated with lipoproteins (Fidge, 1980; Bisgaier 1985; Weinberg 1985; Ohta 1985; Ghiselli 1986) with only small quantities of apoA-IV detected in chylomicrons, very low density and high density lipoproteins. The affinity of apoA-IV to these lipoprotein particles appears to be weak, since apoA-IV is readily displaced by other apolipoproteins (Weisgraber 1978; Rifici 1985) and may easily be dissociated by analytical procedures (e.g. ultracentrifugation; (Green 1980; Bisgaier 1985; Lagrost 1989)). Using high performance gel filtration, however, Lagrost et al. (Lagrost 1989) reported approximately 70% of apoA-IV was present in the larger-sized high density lipoprotein subfraction.

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Author information

Authors and Affiliations

  1. Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bldg. 10/7N117, Bethesda, MD, 20892, USA

    H. Bryan Brewer Jr.

  2. Dept. of Clinical Chemsistry, Klinikum Grobhadern, Marchioninistr. 15, D-8000, Munich 70, Germany

    Peter Lohse

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  1. H. Bryan Brewer Jr.
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  2. Peter Lohse
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Editors and Affiliations

  1. Center E. Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133, Milano, Italy

    Cesare R. Sirtori  & Guido Franceschini  & 

  2. Molecular Disease Branch, National Institutes of Health, NHLBI, 20205, Bethesda, MD, USA

    Bryan H. Brewer Jr.

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© 1993 Springer-Verlag Berlin Heidelberg

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Brewer, H.B., Lohse, P. (1993). Human Apolipoprotein A-IV. In: Sirtori, C.R., Franceschini, G., Brewer, B.H. (eds) Human Apolipoprotein Mutants III. NATO ASI Series, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84634-2_25

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  • DOI: https://doi.org/10.1007/978-3-642-84634-2_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84636-6

  • Online ISBN: 978-3-642-84634-2

  • eBook Packages: Springer Book Archive

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