Human Apolipoprotein Mutants III

Diagnosis and Treatment

  • Cesare R. Sirtori
  • Guido Franceschini
  • Bryan H. BrewerJr.

Part of the NATO ASI Series book series (volume 73)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Enzymes and Apolipoproteins in the Diagnosis of Disease

  3. Structural and Functional Relationships in Apolipoproteins

    1. E. L. Gong, A. V. Nichols, A. R. Tall
      Pages 31-41
    2. G. R. Castro, N. Duverger, P. Duchateau, J. C. Fruchart
      Pages 43-52
    3. A. Jonas, A. von Eckardstein, W. W. Mantulin, G. Assmann
      Pages 53-65
    4. Mark R. Wardell, Charles Wilson, David A. Agard, Robert W. Mahley, Karl H. Weisgraber
      Pages 81-96
    5. David L. Williams, Margaret M. Prack, M. Nicosia, J. T. Gwynne, Mary E. Reyland
      Pages 97-106
  4. Animal Models in the Apolipoprotein Mutant Research

    1. Alan D. Attie, Robert J. Aiello, Scott T. Cooper, Patricia J. Uelmen
      Pages 107-112
  5. Recombinant Apolipoproteins as Drugs

    1. Cesare R. Sirtori
      Pages 121-133
    2. S. L. Sturley, D. G. Gretch, P. D. Friesen, M. R. Culbertson, N. Beckage, A. D. Attie
      Pages 135-143
    3. N. Moguilevsky, F. Varsalona, J.-P. Guillaume, C. Roobol, A. Bollen
      Pages 145-163
  6. Molecular Abnormalities of Apolipoproteins

    1. Philippa Talmud, Alison Dunning, Steve Humphries
      Pages 183-194
    2. C. Gabelli, C. Bilato, S. Martini, G. E. Tennyson, H. B. Brewer Jr, G. Crepaldi et al.
      Pages 195-206
    3. Alberto Corsini, Maria Mazzotti, Tiziano Zanelli, Patrizia Uboldi, Domenico Sommariva, Franco Pazzucconi et al.
      Pages 207-229

About these proceedings

Introduction

Hopes to develop apolipoproteins for diagnostic or, even better, therapeuticpurposes are growing. Areas of use may range from arterial disease to AIDS, fertilization programs, neurological or inflammatory disorders, and the like. However, these young members of the large family of circulating proteins still deserve careful study, both in terms of structural and functional properties and of their pathological changes. In addition, related molecules, in particular belonging to the family of enzymes, such as lipases and acyltransferases, offer exciting insight into the mechanisms of regulation of lipid transport and exchange. Described hereis the use of apolipoproteins and enzymes in the diagnosis of coronary and cerebrovascular disease. Structural and functional changes of apolipoproteins are related to lipid transport and binding to different receptors. Further, the development of apolipoprotein drugs and their possible clinical use for vascular and non vascular disease is discussed and finally an overview on lipoprotein transformation processes, expression systems and natural mutants is provided.

Keywords

AIDS Apolipoproteine Arteriosklerose Atherosklerose Cardiology Kardiologie Koronarkrankheit Lipid apolipoproteins arteriosclerosis atherosclerosis coronoary disease enzymes proteins regulation

Editors and affiliations

  • Cesare R. Sirtori
    • 1
  • Guido Franceschini
    • 1
  • Bryan H. BrewerJr.
    • 2
  1. 1.Center E. Grossi Paoletti, Institute of Pharmacological SciencesUniversity of MilanoMilanoItaly
  2. 2.Molecular Disease BranchNational Institutes of Health, NHLBIBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-84634-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84636-6
  • Online ISBN 978-3-642-84634-2
  • About this book