Abstract
Aging is one of the key contributors to a broad spectrum of chronic diseases. Reactive oxygen species (ROS) increase oxidative stress in cells and thus induces inflammatory cascades. The antioxidant defense systems are declined during aging. Antioxidant controls the oxidative radical process by suppressing the formation of free radicals and interrupting the propagation and initiation of free radicals through several mechanisms. Considering the crucial roles of oxidative stress in age-related diseases, the manipulation of ROS levels would represent a useful option to delay age-related diseases and attenuate associated symptoms. Numerous compounds with antioxidant activity have demonstrated their potential to alleviate age-related diseases; however, mixed results are yielded. Therefore, this chapter discussed the potential of dietary antioxidants against age-related diseases. We also explored on how dietary choices dampen or exacerbate the inflammation and metabolic disorders. Collectively, this information may shed light on the discovery for potential intervention, and thus promoting healthy longevity.
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Tan, B.L., Norhaizan, M.E. (2021). Antioxidant and Age-Related Diseases. In: The Role of Antioxidants in Longevity and Age-Related Diseases . Springer, Cham. https://doi.org/10.1007/978-3-030-82859-2_6
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