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Chaperome Networks – Redundancy and Implications for Cancer Treatment

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HSF1 and Molecular Chaperones in Biology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1243))

Abstract

The chaperome is a large family of proteins composed of chaperones, co-chaperones and a multitude of other factors. Elegant studies in yeast and other organisms have paved the road to how we currently understand the complex organization of this large family into protein networks. The goal of this chapter is to provide an overview of chaperome networks in cancer cells, with a focus on two cellular states defined by chaperome network organization. One state characterized by chaperome networks working in isolation and with little overlap, contains global chaperome networks resembling those of normal, non-transformed, cells. We propose that in this state, redundancy in chaperome networks results in a tumor type unamenable for single-agent chaperome therapy. The second state comprises chaperome networks interconnected in response to cellular stress, such as MYC hyperactivation. This is a state where no redundant pathways can be deployed, and is a state of vulnerability, amenable for chaperome therapy. We conclude by proposing a change in how we discover and implement chaperome inhibitor strategies, and suggest an approach to chaperome therapy where the properties of chaperome networks, rather than genetics or client proteins, are used in chaperome inhibitor implementation.

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Acknowledgements

G.C. is supported by the US National Institutes of Health (NIH) (R01 CA172546, R56 AG061869, R01 CA155226, P01 CA186866, P30 CA08748 and P50 CA192937), the Steven A. Greenberg charitable trust, the Mr. William H. Goodwin and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research and the Experimental Therapeutics Center of the Memorial Sloan Kettering Cancer Center; T.W. is supported by the Lymphoma Research Foundation; M.L.G. is supported by the NIH (R01 CA172546, R01 CA102031), the Irma T. Hirschl/Monique Weill-Caulier Trust and Unravel Pediatric Cancer Foundation.

Author Contributions

P.Y., R.I.P. and M.L.G. researched data for the article and contributed to the writing of the article and to the review of the manuscript. T.W. designed the figures and their content. G.C. designed the content of the manuscript, researched data for the article and wrote, edited and reviewed the manuscript.

Declaration of Interests

Memorial Sloan Kettering Cancer Center holds the intellectual rights to the epichaperome portfolio. Samus Therapeutics, of which G.C. has partial ownership and is a member of its board of directors, has licensed the portfolio. G.C., P.Y. and M.L.G. are inventors on the licensed intellectual property. All other authors declare no competing interests.

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Authors and Affiliations

  1. Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Pengrong Yan, Tai Wang & Gabriela Chiosis

  2. Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA

    Monica L. Guzman

  3. Department of Mathematics, Technical University of Cluj-Napoca, Cluj-Napoca, Romania

    Radu I. Peter

  4. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Gabriela Chiosis

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  1. Pengrong Yan
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  2. Tai Wang
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  3. Monica L. Guzman
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Correspondence to Gabriela Chiosis .

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Editors and Affiliations

  1. Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Marc Laurence Mendillo

  2. University of Chicago, Chicago, IL, USA

    David Pincus

  3. Weizmann Institute of Science, Rehovot, Israel

    Ruth Scherz-Shouval

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Yan, P., Wang, T., Guzman, M.L., Peter, R.I., Chiosis, G. (2020). Chaperome Networks – Redundancy and Implications for Cancer Treatment. In: Mendillo, M.L., Pincus, D., Scherz-Shouval, R. (eds) HSF1 and Molecular Chaperones in Biology and Cancer. Advances in Experimental Medicine and Biology, vol 1243. Springer, Cham. https://doi.org/10.1007/978-3-030-40204-4_6

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