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Developmental Disorders of the Cerebellum and Neurotrophic Factors

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

The cerebellum plays a main role in motor control and also in cognition features such as attention. Thus, a disturbance in cerebellar development results in neurological disorders such as attention deficit hyperactivity disorder (ADHD), congenital ataxia, and autism. Because neurotrophic factors have established effects on the growth, proliferation, differentiation, and arborization of neurons, their role in the neurodevelopmental disorders has been investigated for decades. Results of numerous studies have shown changes in serum or tissue neurotrophic factor levels, as well as alterations in their receptors and components of their signaling pathways in these types of the neurodevelopmental diseases. In this chapter, we provide a brief overview of neurotrophic factors and their role in cerebellar development and then focus on the roles of the neurotrophin system in developmental disorders and diseases of the cerebellum.

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Acknowledgement

Dr. Shala Shojaei Salary was supported by “Health Sciences Centre Foundation General Operating Grant” and MITACS Accelerate award.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

    Leila Pirmoradi

  2. Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

    Ali Akbar Owji

  3. Department of Human Anatomy and Cell Sciences, Faculty of Health Science, College of Medicine, University of Manitoba, Winnipeg, Canada

    Shahla Shojaei

  4. Department of Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

    Shahla Shojaei

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  1. Leila Pirmoradi
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  2. Ali Akbar Owji
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  3. Shahla Shojaei
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Correspondence to Shahla Shojaei .

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  1. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Pirmoradi, L., Owji, A.A., Shojaei, S. (2017). Developmental Disorders of the Cerebellum and Neurotrophic Factors. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-59749-2_7

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