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TGF-β in Dopamine Neuron Development, Maintenance and Neuroprotection

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Development and Engineering of Dopamine Neurons

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 651))

Abstract

Transforming growth factor betas (TGF-βs) are multifunctional cytokines with widespread distribution. In the nervous system the biological effects of TGF-β cover regulation of proliferation, migration, differentiation, survival and death. Specifically, the effects of TGF-β on mesencephalic DAergic neurons extend from induction and specification of the dopaminergic phenotype via promotion of survival to neuroprotection in animal models of parkinsonism. Experimental in vitro and in vivo models have contributed to a better understanding of the putative mechanisms underlying the effects of TGF-β on DAergic neurons and unravelled synergisms between members of the TGF-β superfamily. In this chapter, we will review the literature available with focus on TGF-β proper and glial cell-line-derived neurotrophic factor (GDNF).

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Authors and Affiliations

  1. Institute for Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Albertstrasse 17, D-79104, Freiburg, Germany

    Eleni Roussa, Oliver von Bohlen und Halback & Kerstin Krieglstein

  2. Interdisciplinary Center for Neurosciences Neuroanatomy, University of Heidelberg, Heidelberg, Germany

    Eleni Roussa & Oliver von Bohlen und Halback

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  1. Eleni Roussa
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  2. Oliver von Bohlen und Halback
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  3. Kerstin Krieglstein
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Correspondence to Kerstin Krieglstein .

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Editors and Affiliations

  1. Rudolf Magnus Institute of Neuroscience Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands

    R. Jeroen Pasterkamp PhD , Marten P. Smidt PhD  & J. Peter H. Burbach PhD ,  & 

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Roussa, E., von Bohlen und Halback, O., Krieglstein, K. (2009). TGF-β in Dopamine Neuron Development, Maintenance and Neuroprotection. In: Pasterkamp, R.J., Smidt, M.P., Burbach, J.P.H. (eds) Development and Engineering of Dopamine Neurons. Advances in Experimental Medicine and Biology, vol 651. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0322-8_8

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