Organelle Contact Sites

From Molecular Mechanism to Disease

  • Mitsuo Tagaya
  • Thomas Simmen

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 997)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Saverio Marchi, Mart Bittremieux, Sonia Missiroli, Claudia Morganti, Simone Patergnani, Luigi Sbano et al.
    Pages 49-67
  3. Yuki Ohsaki, Kamil Sołtysik, Toyoshi Fujimoto
    Pages 111-120
  4. Estela Area-Gomez, Eric A. Schon
    Pages 149-156
  5. Nobutaka Hattori, Taku Arano, Taku Hatano, Akio Mori, Yuzuru Imai
    Pages 157-169
  6. Takuma Misawa, Michihiro Takahama, Tatsuya Saitoh
    Pages 187-197
  7. Tetsuro Suzuki
    Pages 199-209
  8. Martijn Kerkhofs, Carlotta Giorgi, Saverio Marchi, Bruno Seitaj, Jan B. Parys, Paolo Pinton et al.
    Pages 225-254
  9. Back Matter
    Pages 255-257

About this book


This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come.

This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.


Mitochondria Mitochondria-associated membrane Membrane contact sites Endoplasmic reticulum Alzheimer’s disease Parkinson’s disease Type II diabetes Hepatitis C virus Cancer Lipid synthesis Apoptosis Calcium Neurodegenerative disease Pathogen infection

Editors and affiliations

  • Mitsuo Tagaya
    • 1
  • Thomas Simmen
    • 2
  1. 1.School of Life SciencesTokyo University of Pharmacy and Life SciencesHachiojiJapan
  2. 2.Department of Cell BiologyUniversity of AlbertaEdmontonCanada

Bibliographic information