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Ceramide Transport from the Endoplasmic Reticulum to the Trans Golgi Region at Organelle Membrane Contact Sites

  • Kentaro Hanada
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 997)

Abstract

Lipids are the major constituents of all cell membranes and play dynamic roles in organelle structure and function. Although the spontaneous transfer of lipids between different membranes rarely occurs, lipids are appropriately transported between different organelles for their metabolism and to exert their functions in living cells. Proteins that have the biochemical capability to catalyze the intermembrane transfer of lipids are called lipid transfer proteins (LTPs). All organisms possess many types of LTPs. Recent studies revealed that LTPs are key players in the interorganelle transport of lipids at organelle membrane contact sites (MCSs). This chapter depicts how LTPs rationally operate at MCSs by using the ceramide transport protein CERT as a typical model for the LTP-mediated interorganelle transport of lipids.

Keywords

Ceramide Sphingomyelin CERT Lipid transfer proteins 

Notes

Acknowledgments

I deeply thank my current and previous co-workers for their invaluable contributions to studies concerning CERT biology. This work was supported by AMED-CREST.

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Biochemistry & Cell BiologyNational Institute of Infectious DiseasesTokyoJapan

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