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Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis

  • Book
  • © 1996

Overview

Editors:
  1. Albert V. G. Bruschke

    1. Department of Cardiology, University Hospital Leiden, Leiden, The Netherlands

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  2. Johan H. C. Reiber

    1. Department of Diagnostic Radiology and Nuclear Medicine, University Hospital Leiden, Leiden, The Netherlands

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  3. K. I. Lie

    1. University of Amsterdam, The Netherlands

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  4. Hein J. J. Wellens

    1. Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 180)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Mechanisms of normal progression and regression

    1. Front Matter

      Pages 1-1
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    2. Role of lipoproteins in progression of coronary arteriosclerosis

      • T. J. C. Van Berkel
      Pages 3-16

    3. Pathophysiological basis for lipid intervention trials

      • H. Buchwald, C. T. Campos
      Pages 17-28

  3. Methodological aspects of angiographic trials

    1. Front Matter

      Pages 29-29
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    2. The use of metabolic measurements in angiographic regression trials

      • G. F. Watts
      Pages 31-43

    3. Quality control in quantitative coronary arteriography

      • J. H. C. Reiber, J. W. Jukema, G. Koning, A. V. G. Bruschke
      Pages 45-63

    4. Is there a place for visual assessment?

      • L. Cashin-Hemphill
      Pages 65-70

    5. Angiographic endpoints in progression trials

      • A. V. G. Bruschke, J. W. Jukema, A. J. Van Boven, E. T. Bal, J. H. C. Reiber, A. H. Zwinderman
      Pages 71-77

  4. Angiographic lipid-lowering clinical trials

    1. Front Matter

      Pages 79-79
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    2. The Cholesterol Lowering Atherosclerosis Study (CLAS)

      • L. Cashin-Hemphill
      Pages 81-84

    3. Clinical efficacy and safety of pravastatin treatment in symptomatic patients — the REGRESS trial

      • J. W. Jukema, A. J. Van Boven, J. H. C. Reiber, A. H. Zwinderman, K. I. Lie, A. V. G. Bruschke
      Pages 85-106

    4. Familial Atherosclerosis Treatment Study

      • V. M. G. Maher
      Pages 107-113

    5. Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC 1): A Summary

      • G. B. J. Mancini
      Pages 115-118

    6. The Multicenter Anti-Atheroma Study (MAAS)

      • The Maas Investigators
      Pages 119-130

    7. Lessons from the Monitored Atherosclerosis Regression Study (MARS) and beyond: atherosclerosis progression/regression responses to therapy depend on lesion size and composition

      • D. M. Kramsch
      Pages 131-141

    8. The St Thomas’ Atherosclerosis Regression Study and an appraisal of its potential limitations

      • G. F. Watts
      Pages 143-150

    9. Effects of the lipid intervention in the Stanford Coronary Risk Intervention Project

      • E. L. Alderman, A. McMillan, W. Haskell
      Pages 151-165

    10. Canadian coronary atherosclerosis study on the effect of lovastatin on the progression of coronary artery disease (CCAIT): why are results different?

      • L. Campeau, J. Lespérance, D. Waters, CCAIT Investigators
      Pages 167-178

    11. Impact upon angiographic disease progression following step drug therapy in normolipidaemic patients: results of the Harvard Atherosclerosis Reversibility Project (HARP)

      • C. M. Gibson, P. H. Stone, R. C. Pasternak, F. M. Sacks, Harvard Atherosclerosis Reversibility Project Group
      Pages 179-191
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Keywords

About this book

A unique overview of all major angiographic lipid intervention trials, presented by their principal investigators. Basic mechanisms and methodological aspects, including biochemical as well as angiographic aspects, are discussed by experts in these fields. A careful comparison of all available data permits an analysis to be made of what may currently be considered proved, which aspects merit further investigation, and which hypotheses should be rejected.
Audience: Clinicians involved in the practice of lipid lowering and investigators involved in lipid-lowering clinical trials. Scientists involved in other areas of lipid research and investigators conducting coronary angiographic trials designed to study the influence of different interventions will find a wealth of information and practical guidelines in this book.

Editors and Affiliations

  • Department of Cardiology, University Hospital Leiden, Leiden, The Netherlands

    Albert V. G. Bruschke

  • Department of Diagnostic Radiology and Nuclear Medicine, University Hospital Leiden, Leiden, The Netherlands

    Johan H. C. Reiber

  • University of Amsterdam, The Netherlands

    K. I. Lie

  • Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands

    Hein J. J. Wellens

Bibliographic Information

  • Book Title: Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis

  • Editors: Albert V. G. Bruschke, Johan H. C. Reiber, K. I. Lie, Hein J. J. Wellens

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-009-0143-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1996

  • Hardcover ISBN: 978-0-7923-3807-9Due: 29 February 1996

  • Softcover ISBN: 978-94-010-6551-1Published: 01 October 2011

  • eBook ISBN: 978-94-009-0143-8Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: 240

  • Topics: Cardiology, Internal Medicine

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