Role of lipoproteins in progression of coronary arteriosclerosis

  • T. J. C. Van Berkel
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 180)

Summary

Lipoproteins are responsible for the transport of cholesterol (esters) and triglycerides. Chylomicron-(remnants), VLDL-remnants (β-VLDL) and (modified) LDL are considered to be atherogenic while high levels of HDL do protect against arteriosclerosis. The liver plays a decisive role in the regulation of the plasma levels of atherogenic lipoproteins. The primary liver interaction site of chylomicron remnants and VLDL remnants (β-VLDL) is still unidentified, whereas the subsequent cellular uptake is likely to be mediated in concert by the LDL-receptor-related protein and the LDL receptor. The nature of the primary interaction site of remnants (remnant receptor) might be a liver-specific proteoglycan or a liver-specific protein. Atherogenic modified LDL can be recognized by a family of scavenger receptors. A newly identified 95-kDa protein forms the most likely candidate for mediating the in-vivo uptake of oxidized LDL from the circulation and may, therefore, protect the body against the presence of oxidized LDL in the blood compartment. HDL do pick up peripheral cholesterol and deliver cholesterol (esters) to the liver. The antiatherogenic action of HDL may reside in specific subfractions containing specific apolipoproteins.

Keywords

Bile Acid Kupffer Cell Cholesteryl Ester Scavenger Receptor Reverse Cholesterol Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers 1996

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  • T. J. C. Van Berkel

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