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Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

  • Book
  • © 2014

Overview

Editors:
  1. Cecile Brocard

    1. Mauerbach, Austria

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  2. Andreas Hartig

    1. Max F. Perutz Laboratories University of Vienna, Vienna, Austria

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  • Provides a comprehensive, well structured state-of-the-art overview on various aspects of peroxisomes cell biology and research

  • A separate part is dedicated to modern technologies such as bioinformatics, proteomics and imaging tools

  • Model organisms to study peroxisome biogenesis ranging from plants to mammals are presented

  • The molecular basis of main peroxisome related disorders are described

  • Includes supplementary material: sn.pub/extras

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Table of contents (23 chapters)

  1. Protein Transport Across the Peroxisomal Membrane

    1. Factors Involved in Ubiquitination and Deubiquitination of PEX5, the Peroxisomal Shuttling Receptor

      • Tony A. Rodrigues, Tânia Francisco, Andreia F. Carvalho, Manuel P. Pinto, Cláudia P. Grou, Jorge E. Azevedo
      Pages 371-388

  2. Peroxisome Dynamic

    1. Front Matter

      Pages 389-389
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    2. Molecular Complex Coordinating Peroxisome Morphogenesis in Mammalian Cells

      • Y. Fujiki, A. Itoyama, Y. Abe, M. Honsho
      Pages 391-401

    3. Peroxisome Proliferation: Vesicles, Reticulons and ER-to-Peroxisome Contact Sites

      • Cécile Brocard
      Pages 403-423

    4. The Functions of Pex11 Family Proteins in Peroxisome Biology

      • Chris Williams, Ida J. van der Klei
      Pages 425-437

    5. Dynamin-Related Proteins in Peroxisome Division

      • Kyaw Aung, Navneet Kaur, Jianping Hu
      Pages 439-460

    6. Plant Peroxisome Dynamics: Movement, Positioning and Connections

      • Imogen Sparkes, Hongbo Gao
      Pages 461-477

  3. Specific Degradation Through Pexophagy

    1. Front Matter

      Pages 479-479
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    2. Molecular Machines Involved in Pexophagy

      • Taras Y. Nazarko, Jean-Claude Farré
      Pages 481-506

    3. Pexophagy Sensing and Signaling in the Methylotrophic Yeasts

      • Andriy A. Sibirny
      Pages 507-527

  4. Back Matter

    Pages 529-543
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Keywords

About this book

In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.

Editors and Affiliations

  • Mauerbach, Austria

    Cecile Brocard

  • Max F. Perutz Laboratories University of Vienna, Vienna, Austria

    Andreas Hartig

About the editors

Cecile Brocard received her PhD in Biochemistry at the University of Vienna, Austria in 1998. She was CIHR post Doctoral fellow at the University of Western Ontario, Medical Sciences, Canada and at the University of Vienna, Austria, where she also was a Guest Professor from 2006 to 2007. In 2007 she became independent research group leader and Elisa Richter Fellow at the Max-F. Perutz Laboratories in Vienna. Since 2012 Cecile has been Head of research in the start up company Tissue Med Biosciences, in Krems an der Donau, Austria.

Andreas Hartig has a PhD in Biochemistry. He was Fogarty Fellow in the Laboratory of Molecular Biology, NINCDS, NIH, Bethesda, USA and Postdoctoral fellow at the Waksman Institute of Microbiology, Rutgers University, in New Jersey and at the Department of Genetics, University of Washington, Seattle, USA. He was research Assistant at the Institute of Biochemistry, University of Vienna, Austria and became Associate Professor in Biochemistry in 1993 where he still works today.

Bibliographic Information

  • Book Title: Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

  • Editors: Cecile Brocard, Andreas Hartig

  • DOI: https://doi.org/10.1007/978-3-7091-1788-0

  • Publisher: Springer Vienna

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Wien 2014

  • Hardcover ISBN: 978-3-7091-1787-3Published: 12 August 2014

  • Softcover ISBN: 978-3-7091-1982-2Published: 17 September 2016

  • eBook ISBN: 978-3-7091-1788-0Published: 23 July 2014

  • Edition Number: 1

  • Number of Pages: XV, 543

  • Number of Illustrations: 17 b/w illustrations, 34 illustrations in colour

  • Topics: Cell Biology, Biological Techniques, Membrane Biology

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