T-type Calcium Channels in Basic and Clinical Science

  • Stephen W. Schaffer
  • Ming Li

Table of contents

  1. Front Matter
    Pages i-x
  2. General Properties of T-Type Ca2+ Channels

    1. Front Matter
      Pages 1-1
    2. Adriano Senatore, J. David Spafford
      Pages 3-17
    3. Norio Hashimoto, Takeshi Kawazu
      Pages 37-48
  3. Role of T-Type Ca2+ Channels in Disease

    1. Front Matter
      Pages 49-49
    2. Marine Warnier, Florian Gackière, Morad Roudbaraki, Pascal Mariot
      Pages 51-71
    3. Stephen W. Schaffer, Chian Ju Jong
      Pages 73-84
    4. Yucai Chen, W. Davis Parker
      Pages 97-111
    5. Jonathan E. Pottle, Lloyd S. Gray
      Pages 113-128
    6. Brian M. Keyser
      Pages 129-136
  4. Back Matter
    Pages 151-154

About this book

Introduction

T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.​

Keywords

T-type Ca-channel calcium channel ion channel

Editors and affiliations

  • Stephen W. Schaffer
    • 1
  • Ming Li
    • 2
  1. 1.Dept. PharmacologyUniversity of South Alabama School of MedicineMobileUSA
  2. 2.Department of PhysiologyTulane University School of MedicineNew OrleansUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-1413-1
  • Copyright Information Springer-Verlag Wien 2015
  • Publisher Name Springer, Vienna
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-7091-1412-4
  • Online ISBN 978-3-7091-1413-1
  • About this book