Magnetic Resonance of Myelin, Myelination, and Myelin Disorders

  • Jacob Valk
  • Marjo S. van der Knaap

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Jacob Valk, Marjo S. van der Knaap
    Pages 1-3
  3. Jacob Valk, Marjo S. van der Knaap
    Pages 4-8
  4. Jacob Valk, Marjo S. van der Knaap
    Pages 9-21
  5. Jacob Valk, Marjo S. van der Knaap
    Pages 26-65
  6. Jacob Valk, Marjo S. van der Knaap
    Pages 66-67
  7. Jacob Valk, Marjo S. van der Knaap
    Pages 68-76
  8. Jacob Valk, Marjo S. van der Knaap
    Pages 77-82
  9. Jacob Valk, Marjo S. van der Knaap
    Pages 83-84
  10. Jacob Valk, Marjo S. van der Knaap
    Pages 85-87
  11. Jacob Valk, Marjo S. van der Knaap
    Pages 88-90
  12. Jacob Valk, Marjo S. van der Knaap
    Pages 91-94
  13. Jacob Valk, Marjo S. van der Knaap
    Pages 95-96
  14. Jacob Valk, Marjo S. van der Knaap
    Pages 97-98
  15. Jacob Valk, Marjo S. van der Knaap
    Pages 99-103
  16. Jacob Valk, Marjo S. van der Knaap
    Pages 104-112
  17. Jacob Valk, Marjo S. van der Knaap
    Pages 113-118
  18. Jacob Valk, Marjo S. van der Knaap
    Pages 119-120
  19. Jacob Valk, Marjo S. van der Knaap
    Pages 121-121

About this book

Introduction

Magnetic resonance imaging (MRI) is now considered the imaging modality of choice for the majority of disorders affecting the central nervous system. This is particularly true for gray and white matter disorders, thanks to the superb soft tis­ sue contrast in MRI which allows gray matter, unmyelinated, and myelinated white matter to be distinguished and their respective disorders identified. The pre­ sent book is devoted to the disorders of myelin and myelination. A growing amount of detailed in vivo information about myelin, myelination, and myelin dis­ orders has been derived both from MRI and from MR spectroscopy (MRS). This prompted us to review the clinical, laboratory, biochemical, and pathological data on this subject in order to integrate all available information and to provide im­ proved insights into normal and disordered myelin and myelination. We will show how the synthesis of all available information contributes to the interpretation of MR images. After a brief historical review about the increasing knowledge on myelin and my­ elin disorders, we propose a new classification of myelin disorders based on the subcellular localization of the enzymatic defects as far as the inborn errors of me­ tabolism are concerned. This classification serves as a guide throughout the book. All items of the classification will be discussed and, whenever relevant and possi­ ble, be illustrated by MR images.

Keywords

Hereditary and acquired white matter disorders Magnetic resonance of white matter disorders Myelin disorders Mylination Nervous System White matter disorders classification magnetic resonance imaging (MRI)

Authors and affiliations

  • Jacob Valk
    • 1
  • Marjo S. van der Knaap
    • 2
  1. 1.Department of Diagnostic Radiology and NeuroradiologyFree University HospitalAmsterdamThe Netherlands
  2. 2.Department of Child NeurologyAcademic HospitalUtrechtThe Netherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-02568-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-02570-3
  • Online ISBN 978-3-662-02568-0
  • About this book