Metachromatic Leukodystrophy

  • Jacob Valk
  • Marjo S. van der Knaap


Metachromatic leukodystrophy (MLD) comprises a group of progressive white matter disorders with autosomal recessive inheritance. The disease can be divided into 4 different subtypes: the congenital, the late infantile, the juvenile and the adult variant. This subdivision is based on the age of onset, the duration, and the clinical picture of the disease. The clinically different forms of MLD are also gentically different. Within one family only one variant of MLD occurs.


White Matter Myelin Sheath Basal Nucleus Metachromatic Leukodystrophy Steroid Sulfate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Jacob Valk
    • 1
  • Marjo S. van der Knaap
    • 2
  1. 1.Department of Diagnostic Radiology and NeuroradiologyFree University HospitalAmsterdamThe Netherlands
  2. 2.Department of Child NeurologyAcademic HospitalUtrechtThe Netherlands

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