Skip to main content
  • Book
  • © 2014

Nano-Oncologicals

New Targeting and Delivery Approaches

Editors:

(view affiliations)
  • Establishes a comprehensive background to any scientist entering the field of cancer nano medicine

  • Revises novel anticancer strategies including targeted therapies, immunomodulation and emerging therapeutic technologies

  • Focuses several chapters on translational aspects for nano-oncologicals, reviewing first-hand experiences from companies working on this area

Part of the book series: Advances in Delivery Science and Technology (ADST)

Buying options

eBook
USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-08084-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 179.99
Price excludes VAT (USA)
Hardcover Book
USD 199.99
Price excludes VAT (USA)

This is a preview of subscription content, access via your institution.

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xiv
  2. Biological Barriers in Cancer

    1. Front Matter

      Pages 1-1
    2. The “EX” and the “SOMA”: How They Communicate

      • Pinar Kanlikilicer, Mohammed Helmy Rashed, Bulent Ozpolat, Cristian Rodriguez-Aguayo, Anil K. Sood, George A. Calin et al.
      Pages 47-63
  3. Tumor Targeting

    1. Front Matter

      Pages 65-65
    2. Polymeric Nanocarriers for Cancer Therapy

      • Peng Mi, Nobuhiro Nishiyama
      Pages 67-94
    3. Targeted Liposomes and Micelles as Carriers for Cancer Therapy

      • Weiyue Lu, Changyou Zhan, Huimin Hou
      Pages 95-122
    4. Photodynamic Therapy for Cancer: Principles, Clinical Applications, and Nanotechnological Approaches

      • Claudia Conte, Francesca Ungaro, Antonino Mazzaglia, Fabiana Quaglia
      Pages 123-160
  4. Targeting the Immune System

    1. Front Matter

      Pages 161-161
    2. Cancer Vaccines: Fundamentals and Strategies

      • Javier Briones
      Pages 163-185
    3. Cancer Immune Modulation and Immunosuppressive Cells: Current and Future Therapeutic Approaches

      • Maria Stella Sasso, Vincenzo Bronte, Ilaria Marigo
      Pages 187-214
    4. Nanotechnology Approaches for Cancer Immunotherapy and Immunomodulation

      • María de la Fuente, Robert Langer, Maria José Alonso
      Pages 215-242
  5. Gene Therapy

    1. Front Matter

      Pages 243-243
    2. RNAi-Based Nano-Oncologicals: Delivery and Clinical Applications

      • Katharina Müller, Ernst Wagner
      Pages 245-268
    3. Nano-Platforms for Tumor-Targeted Delivery of Nucleic Acid Therapies

      • Arun K. Iyer, Shanthi Ganesh, Mansoor M. Amiji
      Pages 269-291
  6. Nanotheranostics

    1. Front Matter

      Pages 293-293
    2. Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

      • João Conde, Furong Tian, Pedro V. Baptista, Jesús M. de la Fuente
      Pages 295-328
    3. Microbubbles as Theranostics Agents

      • Tuan Pham, Carl Beigie, Yoonjee Park, Joyce Y. Wong
      Pages 329-350
    4. Multimodal Nano-Systems for Cancer Diagnosis, Imaging, and Therapy

      • Amit Singh, Adwait J. Oka, Purva Pandya, Mansoor M. Amiji
      Pages 351-388
  7. Translational Aspects of Nano-Oncologicals

    1. Front Matter

      Pages 389-389

About this book

This authoritative volume focuses on emerging technologies in cancer nanomedicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nanotheranostics; and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines).

Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nanocarriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Keywords

  • EPR
  • RNA delivery
  • biomarkers
  • liposomes
  • nanoparticles

Editors and Affiliations

  • Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain

    Maria José Alonso

  • Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain

    Marcos Garcia-Fuentes

About the editors

María José Alonso is Professor of Biopharmaceutics and Pharmaceutical Technology at the University of Santiago de Compostela (USC) in Spain. She has made critical contributions to the design of novel nanostructures for the targeted delivery of drugs and vaccines and to the understanding of the interaction of nanoparticles with biological barriers. She is part of the scientific boards of a number of societies and the executive board of the Controlled Release Society. She is also a member of the editorial board of eight prestigious journals in the field of drug delivery.

Marcos Garcia-Fuentes is an Associate Professor of Pharmacy at Spain’s University of Santiago de Compostela (USC), where he also obtained his Ph.D. He was a visiting scholar at Purdue University in Indiana, USA and a Marie Curie postdoctoral scientist at ETH Zurich in Switzerland. He was recognized with a competitive contract from the regional government for the reintegration of excellent researchers. Marcos has work in the design of biomaterials and nanostructures for medical applications. His current focus is on nanomedicines and biomaterials for modulating progenitor cells and cancer stem cells.

Bibliographic Information

  • Book Title: Nano-Oncologicals

  • Book Subtitle: New Targeting and Delivery Approaches

  • Editors: Maria José Alonso, Marcos Garcia-Fuentes

  • Series Title: Advances in Delivery Science and Technology

  • DOI: https://doi.org/10.1007/978-3-319-08084-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Controlled Release Society 2014

  • Hardcover ISBN: 978-3-319-08083-3

  • Softcover ISBN: 978-3-319-34485-0

  • eBook ISBN: 978-3-319-08084-0

  • Series ISSN: 2192-6204

  • Series E-ISSN: 2192-6212

  • Edition Number: 1

  • Number of Pages: XIV, 473

  • Number of Illustrations: 7 b/w illustrations, 51 illustrations in colour

  • Topics: Pharmaceutics

Buying options

eBook
USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-08084-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 179.99
Price excludes VAT (USA)
Hardcover Book
USD 199.99
Price excludes VAT (USA)