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Nano-Oncologicals pp 187–214Cite as

Cancer Immune Modulation and Immunosuppressive Cells: Current and Future Therapeutic Approaches

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

In the last decade, the role of the immune system in cancer pathology has received growing attention. Immune populations, such as T and B lymphocytes, NK cells, and macrophages, are able to mount an anti-tumor immune response, which can impair tumor growth. Nonetheless, cancer progression is usually associated with the expansion of additional cell subsets that inhibit the natural immunity to tumors and actively support tumor growth, invasion, and metastasis. Their presence represents an obstacle to the effectiveness of cancer immunotherapy. Cells of myeloid origin with strong immunosuppressive and tumor-promoting properties, such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), are major players in this process.

Nanotechnology-based approaches have been recently developed to target MDSCs and TAMs for cancer immunotherapy. Here, these approaches are described, together with other pharmacological and nucleic acid-based strategies, which may take advantage of nanosystems to increase their effectiveness and selectivity. The application of nanotechnology to immunosuppressive and tumor-promoting cell targeting may provide a powerful tool to improve cancer immunotherapy.

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Acknowledgments

This work was supported by grants from the Italian Ministry of Education, University and Research (FIRB project RBAP11T3WB_003 and MIUR project 2009NREAT2_003), Italian Association for Cancer Research (AIRC, Grants IG10400, 12182, AGIMM 100005, and 6599), FP7-NMP-2011(Trans-Int), and Euronanomed 2013 (053 NICHE).

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Authors and Affiliations

  1. Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padova, 35128, Padova, Italy

    Maria Stella Sasso

  2. Department of Pathology, Verona University Hospital, 37134, Verona, Italy

    Vincenzo Bronte

  3. Istituto Oncologico Veneto, IOV-IRCCS, Via Gattamelata, 64, 35128, Padova, Italy

    Ilaria Marigo

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  1. Maria Stella Sasso
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  2. Vincenzo Bronte
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  3. Ilaria Marigo
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Correspondence to Ilaria Marigo .

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  1. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain

    Maria José Alonso

  2. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain

    Marcos Garcia-Fuentes

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Sasso, M.S., Bronte, V., Marigo, I. (2014). Cancer Immune Modulation and Immunosuppressive Cells: Current and Future Therapeutic Approaches. In: Alonso, M., Garcia-Fuentes, M. (eds) Nano-Oncologicals. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-08084-0_7

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