Overview
- Reveals latest discoveries related to the molecular mechanisms of proteasome inhibitor resistance
- Discusses proteasome inhibitor resistance in multiple contexts, including multiple myeloma, leukemia, mantle cell lymphoma, melanoma and other cancers
- Explores multiple, cutting-edge strategies to overcome resistance
- Includes supplementary material: sn.pub/extras
Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics (RTACT)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (15 chapters)
Keywords
About this book
The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume.
This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Resistance to Proteasome Inhibitors in Cancer
Book Subtitle: Molecular Mechanisms and Strategies to Overcome Resistance
Editors: Q. Ping Dou
Series Title: Resistance to Targeted Anti-Cancer Therapeutics
DOI: https://doi.org/10.1007/978-3-319-06752-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2014
Hardcover ISBN: 978-3-319-06751-3Published: 26 September 2014
Softcover ISBN: 978-3-319-37703-2Published: 22 September 2016
eBook ISBN: 978-3-319-06752-0Published: 16 September 2014
Series ISSN: 2196-5501
Series E-ISSN: 2196-551X
Edition Number: 1
Number of Pages: XI, 390
Number of Illustrations: 4 b/w illustrations, 51 illustrations in colour
Topics: Cancer Research, Drug Resistance, Pharmacology/Toxicology, Molecular Medicine