Overview
- Alternative assays for the detection of contact allergens and drug metabolites
- Summarizes the state-of-the art
- Written by experts in the field
- Includes supplementary material: sn.pub/extras
Part of the book series: Experientia Supplementum (EXS, volume 104)
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Table of contents (11 chapters)
Keywords
About this book
This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods.
The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
Editors and Affiliations
Bibliographic Information
Book Title: T Lymphocytes as Tools in Diagnostics and Immunotoxicology
Editors: Stefan F. Martin
Series Title: Experientia Supplementum
DOI: https://doi.org/10.1007/978-3-0348-0726-5
Publisher: Springer Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Basel 2014
Hardcover ISBN: 978-3-0348-0725-8Published: 21 November 2013
eBook ISBN: 978-3-0348-0726-5Published: 09 November 2013
Series ISSN: 1664-431X
Series E-ISSN: 2504-3692
Edition Number: 1
Number of Pages: VI, 184
Number of Illustrations: 6 b/w illustrations, 21 illustrations in colour
Topics: Molecular Medicine, Immunology, Laboratory Medicine