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Assessing Ocular Toxicology in Laboratory Animals

  • Andrea B Weir
  • Margaret Collins

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Robert J. Munger, Margaret Collins
    Pages 23-52
  3. T. Michael Nork, Carol A. Rasmussen, Brian J. Christian, Mary Ann Croft, Christopher J. Murphy
    Pages 53-121
  4. James N. Ver Hoeve, Robert J. Munger, Christopher J. Murphy, T. Michael Nork
    Pages 123-157
  5. Andrea B. Weir, Susan D. Wilson
    Pages 259-294
  6. Back Matter
    Pages 307-319

About this book

Introduction

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes.  Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. 

The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Keywords

Animal Models Ocular Toxicity

Editors and affiliations

  • Andrea B Weir
    • 1
  • Margaret Collins
    • 2
  1. 1.Charles River LaboratoriesSeverna ParkUSA
  2. 2.Charles River LaboratoriesRenoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-164-6
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-62703-163-9
  • Online ISBN 978-1-62703-164-6
  • Series Print ISSN 2168-4219
  • Series Online ISSN 2168-4235
  • Buy this book on publisher's site