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Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment

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Assessing Ocular Toxicology in Laboratory Animals

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

The identification of microscopic toxicologic changes in eyes is influenced by many factors. Important factors include in vivo procedures, such as route of administration to the eye, and procedures involved in preparation of the microscopic ocular sections. A wide variety of toxins may affect all parts of the eye and ocular adnexa and must be differentiated from iatrogenic and spontaneous changes. Both toxic and spontaneous changes may occur in certain species of animals, certain strains of animals, or at certain ages; therefore, a good understanding of potential changes, as well as knowledge of the normal ocular anatomy, physiology, and function, is essential. This chapter focuses on the histologic preparation of ocular tissues and findings involving the anterior segment, uvea, and ocular adnexa and is followed by a chapter focusing on the lens and posterior segment of the eye.

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Authors and Affiliations

  1. Vet Path Services, Inc., Mason, OH, USA

    Kenneth A. Schafer D.V.M., DACVP, FIATP

  2. NAMSA, Northwood, OH, USA

    James A. Render D.V.M., Ph.D., DACVP

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  1. Kenneth A. Schafer D.V.M., DACVP, FIATP
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  2. James A. Render D.V.M., Ph.D., DACVP
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Correspondence to Kenneth A. Schafer D.V.M., DACVP, FIATP .

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  1. Charles River Laboratories, 535 Devonshire Court, Severna Park, 21146, Maryland, USA

    Andrea B Weir

  2. Charles River Laboratories, 6995 Longley Lane, Reno, 89511, Nevada, USA

    Margaret Collins

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Schafer, K.A., Render, J.A. (2012). Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment. In: Weir, A., Collins, M. (eds) Assessing Ocular Toxicology in Laboratory Animals. Molecular and Integrative Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-164-6_5

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