Advertisement

Protein Misfolding and Cellular Stress in Disease and Aging

Concepts and Protocols

  • Peter Bross
  • Niels Gregersen

Part of the Methods in Molecular Biology book series (MIMB, volume 648)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Concepts

    1. Front Matter
      Pages 1-1
    2. Niels Gregersen, Peter Bross
      Pages 3-23
    3. Alicia Mae Pickrell, Carlos Torres Moraes
      Pages 63-78
    4. Dalibor Mijaljica, Mark Prescott, Rodney J. Devenish
      Pages 79-92
    5. Dalibor Mijaljica, Mark Prescott, Rodney J. Devenish
      Pages 93-106
    6. Rajiv Vaid Basaiawmoit, Suresh I. S. Rattan
      Pages 107-117
    7. Peter Bross, Johan Palmfeldt, Jakob Hansen, Søren Vang, Niels Gregersen
      Pages 119-135
  3. Protocols

    1. Front Matter
      Pages 137-137
    2. Kanako Wakabayashi-Nakao, Ai Tamura, Shoko Koshiba, Yu Toyoda, Hiroshi Nakagawa, Toshihisa Ishikawa
      Pages 139-159
    3. Natalia A. Kaniuk, John H. Brumell
      Pages 175-182
    4. Cristovao F. Lima, Suresh I. S. Rattan
      Pages 183-192
    5. Isei Tanida, Satoshi Waguri
      Pages 193-214
    6. Tomoyuki Yamanaka, Nobuyuki Nukina
      Pages 215-229
    7. Anatoly A. Starkov
      Pages 245-255
    8. Joshua B. Owen, D. Allan Butterfield
      Pages 269-277
    9. Jakob Hansen, Peter Bross
      Pages 303-311
    10. Raymond C. Stevens, Javier Sancho, Aurora Martinez
      Pages 313-324
  4. Back Matter
    Pages 325-330

About this book

Introduction

How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can counteract, modify, or delay the consequences of misfolding. The volume begins with several concepts and approaches developed in the recent past including a connection to the research field of aging, where protein misfolding diseases have been equated to premature aging processes, and the book’s coverage continues with detailed descriptions of protocols for relevant experimental approaches. Written in the highly successful Methods in Molecular Biology™ series format, protocols chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols aims to aid researchers in the field, as well as medical professionals and molecular biologists, in shaping and performing research related to this intriguing and vital subject.

Keywords

Disease processes Endoplasmatisches Reticulum Pathogenetic mechanisms Premature aging Termination Treatment strategies Vivo electron microscopy genes molecular biology proteins tissue transcription

Editors and affiliations

  • Peter Bross
    • 1
  • Niels Gregersen
    • 2
  1. 1.Aarhus University Hospital, Research Unit for Molecular MedicineUniversity of AarhusAarhus NDenmark
  2. 2.Aarhus University Hospital, Research Unit for Molecular MedicineUniversity of AarhusAarhus NDenmark

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-756-3
  • Copyright Information Springer Science + Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-755-6
  • Online ISBN 978-1-60761-756-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site