Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

  • Avraham Yacobi
  • Jerome P. Skelly
  • Vinod P. Shah
  • Leslie Z. Benet

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction

  3. Preclinical Pharmacokinetic & Pharmacodynamic Studies

  4. Methodology for Preclinical Pharmacodynamic Studies

    1. M. Danhof, J. W. Mandema, A. Hoogerkamp
      Pages 69-80
    2. Robert A. Branch, Edwin K. Jackson
      Pages 81-89
    3. Asoke Mukherjee, Conrad Chen, Lucy Jean, Claude B. Coutinho
      Pages 105-113
  5. Preclinical & Clinical Pharmacokinetics

    1. Avraham Yacobi, Vijay K. Batra, Robert E. Desjardins, Robert D. Faulkner, Gabriela Nicolau, William R. Pool et al.
      Pages 125-135
    2. Thaddeus H. Grasela Jr., Edward J. Antal
      Pages 137-148
  6. Clinical Pharmacodynamics

    1. Davide Verotta, Lewis B. Sheiner
      Pages 159-177

About this book

Keywords

drug drug development kinetics metabolism pharmaceutical pharmacodynamics pharmacokinetics pharmacology research

Editors and affiliations

  • Avraham Yacobi
    • 1
  • Jerome P. Skelly
    • 2
  • Vinod P. Shah
    • 3
  • Leslie Z. Benet
    • 4
  1. 1.Pharmacodynamics ResearchAmerican Cyanamid Company, Medical ResearchPearl RiverUSA
  2. 2.Office of Research Resources, Center for Drug Evaluation and ResearchFood and Drug AdministrationUSA
  3. 3.Office of Generic Drugs, Center for Drug Evaluation and ResearchFood and Drug AdministrationRockvilleUSA
  4. 4.Department of Pharmacy, School of PharmacyUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-1520-0
  • Copyright Information Springer-Verlag US 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-1522-4
  • Online ISBN 978-1-4757-1520-0
  • About this book