Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

  • Avraham Yacobi
  • Jerome P. Skelly
  • Vinod P. Shah
  • Leslie Z. Benet

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction

  3. Preclinical Pharmacokinetic & Pharmacodynamic Studies

  4. Methodology for Preclinical Pharmacodynamic Studies

    1. M. Danhof, J. W. Mandema, A. Hoogerkamp
      Pages 69-80
    2. Robert A. Branch, Edwin K. Jackson
      Pages 81-89
    3. Asoke Mukherjee, Conrad Chen, Lucy Jean, Claude B. Coutinho
      Pages 105-113
  5. Preclinical & Clinical Pharmacokinetics

    1. Avraham Yacobi, Vijay K. Batra, Robert E. Desjardins, Robert D. Faulkner, Gabriela Nicolau, William R. Pool et al.
      Pages 125-135
    2. Thaddeus H. Grasela Jr., Edward J. Antal
      Pages 137-148
  6. Clinical Pharmacodynamics

  7. Application of Pharmacodynamics & Pharmacokinetics in the Drug Development Process

    1. Sally Usdin Yasuda, Sorell L. Schwartz, Anton Wellstein, Raymond L. Woosley
      Pages 225-238
    2. Lilly P. Sanathanan, Carl C. Peck
      Pages 239-247
  8. Summary Report

    1. Carl C. Peck, William H. Barr, Leslie Z. Benet, Jerry Collins, Robert E. Desjardins, Daniel E. Furst et al.
      Pages 249-263
  9. Back Matter
    Pages 265-270

About this book


drug drug development kinetics metabolism pharmaceutical pharmacodynamics pharmacokinetics pharmacology research

Editors and affiliations

  • Avraham Yacobi
    • 1
  • Jerome P. Skelly
    • 2
  • Vinod P. Shah
    • 3
  • Leslie Z. Benet
    • 4
  1. 1.Pharmacodynamics ResearchAmerican Cyanamid Company, Medical ResearchPearl RiverUSA
  2. 2.Office of Research Resources, Center for Drug Evaluation and ResearchFood and Drug AdministrationUSA
  3. 3.Office of Generic Drugs, Center for Drug Evaluation and ResearchFood and Drug AdministrationRockvilleUSA
  4. 4.Department of Pharmacy, School of PharmacyUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information