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Abstract

Ten critical pharmacokinetic and pharmacodynamic parameters should be determined for each new drug, both in test animal species and in man. These ten parameters, listed in order of importance, are: 1) clearance, 2) effective concentrations, 3) extent of availability, 4) fraction of the available dose excreted unchanged, 5) the blood/plasma concentration ratio, 6) half-life, 7) toxic concentrations, 8) protein binding, 9) volume of distribution, and 10) rate of availability.

Keywords

Hepatic Blood Flow Extraction Ratio Oral Dosage Form Drug Development Process Plasma Concentration Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Leslie Z. Benet
    • 1
  1. 1.Department of PharmacyUniversity of CaliforniaSan FranciscoUSA

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