Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs
Several different classes of drugs are used in clinical anesthetic practice. These include muscle paralyzing drugs, potent inhalational anesthetics, intravenous hypnotics and opioids. The measurement of drug effect for each of these classes differs in complexity and resolution. Many concepts of drug pharmacokinetic and pharmacodynamic modeling have been developed with anesthetic drugs. This has occurred because the drug effects are generally profound, can be quantitated in a reasonable manner and are relatively rapid in onset. Understanding anesthetic clinical pharmacology and therapeutics is intimately linked to pharmacokinetic and pharmacodynamic modeling concepts.
KeywordsNitrous Oxide Drug Effect Minimum Alveolar Concentration Anesthetic Drug Pharmacodynamic Modeling
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