Overview
- Editors:
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Linda L. Gallo
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The George Washington University Medical Center, USA
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About this book
The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.
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Table of contents (59 chapters)
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Vessel Wall Biology
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- Linda L. Slakey, Ellen L. Gordon
Pages 323-328
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- A. Etienne, N. Baroggi, P. Braquet
Pages 329-334
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Atherosclerosis
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Front Matter
Pages 335-335
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- Robert W. Wissler, Dragoslava Vesselinovitch
Pages 337-357
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- Jason C. H. Shih, Roman Pyrzak
Pages 359-364
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- Motoomi Nakamura, Hitonobu Tomoike, Kensuke Egashira
Pages 365-368
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- Marc J. T. M. Mol, Anton F. H. Stalenhoef
Pages 369-372
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- Thomas B. Clarkson, Michael R. Adams, Jay R. Kaplan, Donald R. Koritnik
Pages 373-379
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- Michael R. Adams, Jay R. Kaplan, Thomas B. Clarkson, Donald R. Koritnik
Pages 381-387
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- Donald B. Hunninghake, Jeffrey R. Peters
Pages 397-405
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- Ralph G. DePalma, Errol M. Bellon, P. M. Manalo, Richard A. Bomberger
Pages 407-426
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- Rosemary Zaragoza, Guy C. Le Breton
Pages 427-435
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- Jeffrey M. Hoeg, Martha B. Maher, Kent R. Bailey, Silvia S. Fojo, H. Bryan Brewer Jr.
Pages 437-442
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- Juan Jose Badimon, Lina Badimon, Angel Galvez, Valentin Fuster
Pages 443-451
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Atherosclerosis
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Front Matter
Pages 453-453
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- R. Saynor, T. Gillott, T. Doyle
Pages 455-461
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- Isabel S. Chen, Satchithanandam Subramanian, Marie M. Cassidy, George V. Vahouny, Alan J. Sheppard
Pages 463-481
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- D. Lapous, C. Loriette, J. Raulin, C. Wolfrom, M. Gautier
Pages 483-493
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- Gundu H. R. Rao, Nanda P. Kishore, Janet D. Peller, James G. White
Pages 495-505
Editors and Affiliations
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The George Washington University Medical Center, USA
Linda L. Gallo