Overview
- Editors:
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Henk L. Granzier
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Washington State University, Pullman, USA
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Gerald H. Pollack
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University of Washington, Seattle, USA
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Table of contents (24 chapters)
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Elastic Filaments of The Cell
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Elastic Filaments of the Cell
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- Koscak Maruyama, Sumiko Kimura
Pages 25-33
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- Thomas Centner, Francoise Fougerousse, Alexandra Freiburg, Christian Witt, Jacque S. Beckmann, Henk Granzier et al.
Pages 35-52
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- Marion L. Greaser, Seu-Mei Wang, Mustapha Berri, Paul Mozdziak, Yashiyuki Kumazawa
Pages 53-66
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- Abigail S. McElhinny, Siegfried Labeit, Carol C. Gregorio
Pages 67-88
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- Joseph W. Sanger, Joseph C. Ayoob, Prokash Chowrashi, Daniel Zurawski, Jean M. Sanger
Pages 89-110
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Molecular Mechanism of Elasticity
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Front Matter
Pages 111-111
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- Miklós S. Z. Kellermayer, Steven Smith, Carlos Bustamante, Henk L. Granzier
Pages 111-128
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- Matthias Rief, Mathias Gautel, Hermann E. Gaub
Pages 129-141
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- Hui Lu, André Krammer, Barry Isralewitz, Viola Vogel, Klaus Schulten
Pages 143-162
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- Larissa Tskhovrebova, John Trinick
Pages 163-178
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Titin-Like Proteins
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Front Matter
Pages 207-207
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- Belinda Bullard, David Goulding, Charles Ferguson, Kevin Leonard
Pages 207-220
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- Cristina Machado, Deborah J. Andrew
Pages 221-236
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- Jim O. Vigoreaux, Jeffrey R. Moore, David W. Maughan
Pages 237-250
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- Agnes Ayme-Southgate, Richard Southgate, Michelle Kulp McEliece
Pages 251-264
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- Thomas C. S. Keller III, Kenneth Eilertsen, Mark Higginbotham, Steven Kazmierski, Kyoung-Tae Kim, Michaella Velichkova
Pages 265-281
About this book
Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.
Editors and Affiliations
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Washington State University, Pullman, USA
Henk L. Granzier
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University of Washington, Seattle, USA
Gerald H. Pollack